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EC number: 221-117-5
CAS number: 3007-53-2
The potential of N,N Dimethyldodecane-1-amide to cause dermal
corrosion/irritation was assessed by a single topical application of 50
μL (corrosion test) or 30 μL (irritation test) of the undiluted test
substance to a reconstructed three dimensional human epidermis model
For the corrosion test two EpiDerm™ tissue samples were incubated with
the test substance for 3 minutes and 1 hour, respectively. The
irritation test was performed with three EpiDerm™ tissue samples, which
were incubated with the test substance for 1 hour followed by a 42-hours
post-incubation period. Tissue destruction was determined by measuring
the metabolic activity of the tissue after exposure/post-incubation
using a colorimetric test. The reduction of mitochondrial dehydrogenase
activity, measured by reduced formazan production after incubation with
a tetrazolium salt (MTT) was chosen as endpoint. The formazan production
of the testsubstance treated epidermal tissues is compared to that of
negative control tissues. The quotient of the values indicates the
relative tissue viability.
The EpiDerm™ skin corrosion/irritation test showed the following results:
The test substance is able to reduce MTT directly. However, this ability
of direct MTT reduction did not impair the study result as demonstrated
by the concurrently performed exposure of control tissues inactivated by
freezing (performed with corrosion test, only).
Corrosion test: The mean viability of the test-substance treated tissues
determined after an exposure period of 3 minutes was 103%, and it was
104% after an exposure period of 1 hour.
The mean viability of the test-substance treated tissues determined
after an exposure period of 1 hour with about 42 hours post-incubation
Based on the observed results it was concluded, that N,N
Dimethyldodecane-1-amide shows a skin irritation potential in the
EpiDerm™ skin corrosion/irritation test under the test conditions chosen.
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