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EC number: 221-117-5
CAS number: 3007-53-2
ASSESSMENT AND DISCUSSION:
The test substance as an aerosol proved to have a relatively low acute
inhalative toxicity in the rat up to the maximum tested concentration of
3551 mg/m3 air.
A single 4-hour exposure to 3551 mg/m3 air resulted in relatively
persistent respiratory disorders considered to be causally related to a
primary irritant effect on the respiratory tract. The hypothermia
determined from 586.4 mg/m3 air is considered to be causally related to
the aerosol's local irritant potential.
A study for acute inhalation toxicity was conducted with "confidential
substance name" in accordance with OECD Guideline No. 403.
Therefore 5 SPF-bred Wistar rats were exposed (head/nose only) to 118.5;
586.4; 2007.6 and 3550.7 mg/m3 (analytical determined).
Rats subjected to a concentration of 119 mg/m3 air tolerated the
exposure without signs occurring. Rats exposed to 586 mg/m3 air
exhibited a transient reddening of the nose on the day of exposure and
reduced motility. Rats subjected to the max. tested concentration (3551
mg/m3 air; nebulization of the undiluted test article) exhibited
persistent signs causally linked to an irritation of the respiratory
tract (slower breathing, serous nasal discharge, dyspnea, stridor,
hypothermia). 3551 mg/m3 air was the range at which mortality started
for male rats (1 of 5 died). The results of this study show that the
respirable test article aerosol had a relatively low acute inhalative
toxic effect on the rat. The acute potential hazard of the respiratory
tract is attributed to the potency of the test substance aerosol to act
as a mucosa irritant. LC50 inhalation (aerosol) Rat (exposure: 4 h) >
3551 mg/m3 air
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