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EC number: 205-619-1 | CAS number: 144-19-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP study conducted using sound scientific principles
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: Methods for Acute Toxicity Tests with Fish, Macroinvertebrates & Amphibians (USEPA, 1975)
- Deviations:
- yes
- Remarks:
- exposure concentrations not analytically verified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 2,2,4-trimethylpentane-1,3-diol
- EC Number:
- 205-619-1
- EC Name:
- 2,2,4-trimethylpentane-1,3-diol
- Cas Number:
- 144-19-4
- Molecular formula:
- C8H18O2
- IUPAC Name:
- 2,2,4-trimethylpentane-1,3-diol
- Details on test material:
- - Name of test material (as cited in study report): BO944.01
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- The dilution water used was soft water reconstituted fromdeionized water. The test solutions were prepared by the direct addition of the appropriate quantity of test substance and a proportional ammount of acetone to 15 liters of dilution water.
Test organisms
- Test organisms (species):
- Lepomis macrochirus
- Details on test organisms:
- The bluegill (Bionomics lot # 85A33b) were obtained from a commercial supplier in Missouri. The mean wet weight of the test fish population was 0.52 g (range 0.30 - 0.67 g, N=30) and the mean total length was 36 mm (range 27-40 mm, N=30). The fish were maintained in the lab at least 14 days prior to the test. They were fed a dry commercial pelleted food, ad libitum, daily except during the 48 hours prior to testing. There was no mortality of the test fish population during this 48-hour period.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Hardness:
- 41 mg/L as CaCO3
- Test temperature:
- 22 + or - 1C
- pH:
- 7.2
- Nominal and measured concentrations:
- 700, 420, 250, 150 and 91 mg/L nominal
- Details on test conditions:
- The toxicity test was conducted in 18.9-L glass aquaria which contained 15L of test solution. The test solution depth was 18 cmwith a surface area of 985 cm2. Two control aquaria were established containing the same dilution water and maintained under the same conditions as the test aquaria containing the test substance. One control aquaria contained the greatest amount of acetone vehicle present in any test vessel (0.33 mg/L) and was designated the solvent control. The test temperature was maintained at 22 + or - 1C and the solutions were not aerated. The photoperiod was controled as 16 hours light and 8 hours darkness. Ten bluegill selected impartially from the holding tank were placed in each test aquaria within 20 minutes after the test solutions had been prepared. The resulting test organism loading concentration was 0.35 g of biomass per liter of test solution. The fish were not fed during the exposure. All aquaria were examined after 0, 24, 48, 72 96 hours of exposure as follows: mortalities were recorded, dead fish were removed, and observations of the fish and physical characteristics of the test solutions were recorded.
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 700 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 420 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Details on results:
- No mortality was observed in the control, solvent control, and test substance concentrations up to and including 420 mg/L. In the 700 mg/L test concentration 20% mortality was observed at 24 hours and ddi not increase over the remaining exposure period.
Applicant's summary and conclusion
- Executive summary:
A 96 -hour static acute toxicity tests was conducted with TMPD using bluegill (Lepomis macrochirus) utilizing a method equivilent to U.S. Environmental Protection Agency Methods for Acute Toxicity Tests with Fish, Macroinvertebrates & Amphibians. The exposure was conducted using nominal concentrations of the test substance at 91, 150, 250, 420 and 700 mg/L. The LC50 was determined to be > 700 mg/L, the highest concentration tested. The NOEC was 420 mg/L.
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