Registration Dossier
Registration Dossier
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EC number: 204-066-3 | CAS number: 115-11-7
Categories
- Category name:
- 1,2-butadiene read across
Justifications and discussions
- Category definition:
- C4 alkene hydrocarbons, read-across framework for 1,2-butadiene
- Category description:
- 1,2-butadiene, 1-butene, 2-butene, 2-methylpropene, 1,3-butadiene
- Category rationale:
- The analogue approach is being applied to C4 hydrocarbons with one or two alkene (olefin) moieties, i.e. carbon-carbon double bonds. These substances are all gaseous at room temperature and pressure, and the inhalation route is expected to be the predominant, and only significant, route of exposure. The alkene moiety is susceptible to oxidation by cytochrome P450 isozymes (in particular 2A6 and 2E1) resulting in epoxide and diepoxide metabolites that may react with cellular nucleophiles. The epoxides may also be hydrolysed by epoxide hydrolase to diol metabolites, or react with glutathione, catalysed by glutathione-S-transferase. Hydrolysis and conjugation with GSH are considered to be routes of detoxification.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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