Registration Dossier
Registration Dossier
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EC number: 203-079-1 | CAS number: 103-09-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented study
Data source
Reference
- Reference Type:
- publication
- Title:
- Zur arbeitshygienisch-toxikologischen Beurteilung volkswirtschaftlich bedeutsamer chemischer Substanzen. 4. Kurzmitteilung: Technisches 2-Aethylhexylacetat (Octylacetat).
- Author:
- Schmidt P, Bachmann W
- Year:
- 1 969
- Bibliographic source:
- Z Gesamte Hyg. 15(12): 928-929
Materials and methods
- Principles of method if other than guideline:
- Study to assess the acute oral toxicity in rats.
- GLP compliance:
- no
- Test type:
- other: no data
- Limit test:
- no
Test material
- Reference substance name:
- 2-ethylhexyl acetate
- EC Number:
- 203-079-1
- EC Name:
- 2-ethylhexyl acetate
- Cas Number:
- 103-09-3
- Molecular formula:
- C10H20O2
- IUPAC Name:
- 2-ethylhexyl acetate
- Details on test material:
- 2-ethylhexyl acetate, technically pure
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albino
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own breeding (randomized)
- Weight at study initiation: 161 (150-180) g
- Fasting period before study: 18 h
- Diet Standard diet K (VEG Altglienecke, Germany) ad libitum
- Water ad libitum
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- no data
- Doses:
- 4 doses (unspecified)
- No. of animals per sex per dose:
- 10
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 4 weeks (necropsy)
- Statistics:
- The calculation of the LD50 was done according to Litchfield and Wilcoxon. The differences were significant, if p<0.05 was calculated in the t-test.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 5 140 mg/kg bw
- 95% CL:
- 4 450 - 5 950
- Remarks on result:
- other: value 48 h after administration
- Mortality:
- Deaths occurred predominantly within the first 24 hours after appliaction.
- Clinical signs:
- other: Little excitation, narcosis.
- Gross pathology:
- Animals that died: Uncharacteristic blood congestion in the interior organs.
Sacrificed animals: no macroscopic changes were observed after the autopsy.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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