Chlorodimethylvinylsilane

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2002-05-10 to 2002-07-08

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study was conducted in accordance with an appropriate OECD test guideline and in compliance with GLP. The read across is justified and the original reliability of the study is 1. The read across is considered reliability 2.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2002

Report date:

2002

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Chlorodimethylvinylsilane

EC Number:

217-007-1

EC Name:

Chlorodimethylvinylsilane

Cas Number:

1719-58-0

Molecular formula:

C4H9ClSi

IUPAC Name:

chloro(dimethyl)vinylsilane

Test animals

Species:

rat

Strain:

other: Crl:CD

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS- Source: Charles River Deutschland GmbH, Sulzfeld, GERMANY- Age at study initiation: 42 d (m), 50 d (f)- Weight at study initiation: 203-283 g (m), 170-190 g (f)- Housing: 2-3/Makrolon Type III cage- Diet: standard diet ad libitum- Water: drinking water ad libitum- Acclimation period: at least 5 daysENVIRONMENTAL CONDITIONS- Temperature (°C): 22 +/- 3- Humidity (%): 55 +/- 15- Air changes (per hr): not stated - Photoperiod (hrs dark / hrs light): 12 h/12 hIN-LIFE DATES: From: unclear To: 2002-07-08

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

corn oil

Remarks:

for the 200 mg/kg bw dose only

Details on oral exposure:

VEHICLEcorn oil- Lot/batch no. (if required): 81K2204MAXIMUM DOSE VOLUME APPLIED: 2.27 mg/kg bw

Doses:

2000 mg/kg bw (m)200 mg/kg bw (m/f)

No. of animals per sex per dose:

3

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days - Frequency of observations and weighing: clinical observations at 5, 15, 30 and 60 minutes; 3, 6 and 24 h and then daily for 14 days. Body weights - weekly.- Necropsy of survivors performed: yes- Other examinations performed: clinical signs, body weight, histopathology of tissues with evident lesions

Statistics:

None

Results and discussion

Effect levels

Effect levels 1

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 200 mg/kg bw

Based on:

test mat.

Remarks on result:

other: No deaths and no overt signs of systemic toxicity.

Effect levels 2

Sex:

male

Dose descriptor:

LD100

Effect level:

2 000 mg/kg bw

Based on:

test mat.

Mortality:

2000 mg/kg bw: 3/3 (m)200 mg/kg bw 0/3 males; 0/3 females

Clinical signs:

other: 2000 mg/kg bw (3m): reduced motility, ataxia in all animals, reduced muscle tone, dyspnoea and vocalisation in one.200 mg/kg bw (3m/3f): no overt signs of toxicity

Gross pathology:

Nothing remarkable reported

Any other information on results incl. tables

Table 1: Number of animals dead or with evident toxicity

Dose (mg/kg bw)	Mortality (dead/total)			Time range of deaths	Number with evident toxicity
	Male	Female	Combined		Male	Female
2000	3/3	-	3/3	Within 30 minutes	3/3:reduced motility, ataxia 1/3: reduced muscle tone, dyspnoea and vocalisation	-
200	0/3	0/3	0/6	-	0/3 died and no clinical signs or effect on body weight	0/3 died and no clinical signs or effect on body weight

 

Applicant's summary and conclusion

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated informationCriteria used for interpretation of results: EU

Conclusions:

A reliable study conducted largely in compliance with a standard guideline and GLP, identified an acute oral LD50 between 200 and 2000 mg/kg bw for male and females rats, treated via gavage.