Registration Dossier
Registration Dossier
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Reaction mass of 2-[[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]methyl]oxirane and 1,3-bis[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol and 1-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-3-[4-[[4-[3-[4-[[3,5-dimethyl-4-(oxiran-2-ylmethoxy)phenyl]methyl]-2,6-dimethyl-phenoxy]-2-hydroxy-propoxy]-3,5-dimethyl-phenyl]methyl]-2,6-dimethyl-phenoxy]propan-2-ol
EC number: 941-357-0 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 4.47
- Temp.:
- 25 °C
- pH:
- >= 7.03 - <= 7.57
- Type:
- Pow
- Partition coefficient:
- 29 428.7
- Temp.:
- 25 °C
- pH:
- >= 7.03 - <= 7.57
- Details on results:
- Log P result the mean of triplicate samples (each analysed in duplicate).
- Conclusions:
- The Pow of the test material was determined to be 29428.7 (Log Pow 4.47), measured at 25°C, using the shake-flask method.
Reference
Consistent low recoveries were obtained for both the n-Octanol stock solutions and individual layers. These are consistent with low recoveries obtained for check standards, indicating a possible weighing error associated with the calibration standard. However, as the partition calculations are based on the concentration ratios and not on absolute concentrations, the low recoveries are deemed insignificant and the reported result is considered valid.
Description of key information
The shake flask method was applied for the determination of the partition coefficient (Pow) of the test substance.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 4.47
- at the temperature of:
- 25 °C
Additional information
The partition coefficient was determined to be 29428.7 (Log Pow 4.47).
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