Registration Dossier
Registration Dossier
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EC number: 204-442-7 | CAS number: 121-00-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment of Butylated Hydroxyanisole
- Year:
- 1 984
- Bibliographic source:
- International Journal of Toxicology September/October 1984 3: 83-146,
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from International Journal of Toxicology
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-tert-butyl-4-methoxyphenol
- EC Number:
- 204-442-7
- EC Name:
- 2-tert-butyl-4-methoxyphenol
- Cas Number:
- 121-00-6
- Molecular formula:
- C11H16O2
- IUPAC Name:
- 2-tert-butyl-4-methoxyphenol
- Details on test material:
- - Name of test material (as cited in study report): tert-butyl-4-methoxyphenol
- Substance type: Organic
- Physical state: Solid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Reversibility:
- no data
- Remarks on result:
- other: Formulations containing tert-butyl-4-methoxyphenol (BHA)showed, at most, minimal to moderate skin irritation in rabbits.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Formulations containing tert-butyl-4-methoxyphenol (BHA)showed, at most, minimal to moderate skin irritation in rabbits. and it can be concluded the the tert-butyl-4-methoxyphenol is not irritating to skin based on not sufficient infromation available for classification as the per the CLP criteria.
- Executive summary:
Formulations containing tert-butyl-4-methoxyphenol (BHA)showed, at most, minimal to moderate skin irritation in rabbits. and it can be concluded the the tert-butyl-4-methoxyphenol is not irritating to skin based on not sufficient infromation available for classification as the per the CLP criteria.
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