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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The substance is not classified as irritating to skin and eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Multicase model
GLP compliance:
no
Species:
other: no data
Strain:
not specified
Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
no data
Remarks on result:
other: Skin irritation: negative i.e; non-irritating
Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .
Executive summary:

Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to guideline
Guideline:
other:
Principles of method if other than guideline:
Data is from QSAR toolbox Version 2.3
GLP compliance:
not specified
Species:
rabbit
Strain:
not specified
Vehicle:
not specified
Controls:
not specified
Irritation parameter:
other: MMAS(modified maximum average score (MMAS))
Basis:
mean
Score:
0.94
Reversibility:
not specified
Remarks on result:
other: non irritating

The prediction was based on dataset comprised from the following descriptors: MMAS
Estimation method: Taking average value from the 5 nearest neighbours
Domain logical expression:Result: In Domain

(("a" and "b" ) and ("c" and "d" ) )

Domain logical expression index: "a"

Similarity boundary:Target: C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=50%,
Dice(Atom pairs)

Domain logical expression index: "b"

Similarity boundary:Target: C(C)(C)(C)c1c(O)ccc(OC)c1
Threshold=80%,
Dice(Atom pairs)

Domain logical expression index: "c"

Parametric boundary:The target chemical should have a value of log Kow which is >= 2.56

Domain logical expression index: "d"

Parametric boundary:The target chemical should have a value of log Kow which is <= 4.22

Interpretation of results:
not irritating
Remarks:
Migrated information 0.94 Criteria used for interpretation of results: EU
Conclusions:
By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).
Executive summary:

By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation / corrosion :

Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .

The other authoritative supporting sources of information indicates that tert-butyl-4-methoxyphenol exhibit moderate skin irritant effect when applied on rabbit skin. However, for the purpose of the chemical safety report the experimental value will be considered.

Eye irritation :

By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).


Justification for selection of skin irritation / corrosion endpoint:
Tert-butyl-4-methoxyphenol gives negative result i.e. not irritating to skin as estimated by the Multicase model from Danish QSAR .

Justification for selection of eye irritation endpoint:
By Modified maximum average score (MMAS) from prediction done using QSAR toolbox for eye irritation score of tert-butyl-4-methoxyphenol estimated as 0.94. This score indicates that tert-butyl-4-methoxyphenol is not irritating to the eye of rabbit.(as the criteria MMAS <25 is not irritating).

Justification for classification or non-classification