Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 618-882-6
CAS number: 928771-01-1
Results are available from two modern, GLP-compliant, guideline studies that have assessed the acute toxicity of NExBTL renewable diesel in the rat following oral or dermal exposure. The LD50 in both instances exceeded 2000 mg/kg bwt. No information is available, or required (column 2 of REACH Annex VIII; 8.5.2), for acute toxicity after inhalation exposure as the available data indicate that the LC50 will exceed the saturated vapour pressure of the substance.
Acute oral toxicity (acute toxic class
method, method B1 of directive 2004/73/EC) and acute dermal toxicity
(method B3 of directive 2004/73/EC) were determined in the rat. In both
studies the test substance was administered neat at 2000 mg/kg bwt. Both
studies were GLP-compliant, and the information is reliable and fully
adequate for evaluation. There were no deaths, unusual clinical signs or
necropsy findings in either study.
The acute inhalation toxicity of a series on
C9-C13 n-alkanes was investigated in male SD rats following a single
8-hr exposure to vapour. A calculated LC50 of 4467 ppm (equivalent to
23.4 mg/l) was determined for n-nonane. Given the extended duration of
exposure used in these studies, the 4 -hr LC50 is likely to exceed this
value. No mortality was recorded for C10 -C13 n-alkanes after exposure
to the maximum achievable vapour concentration in air. The maximum
saturated vapour concentration decreased in a predictable manner with
increasing C-number. It is concluded, based on these findings, that the
acute (4 -hr) inhalation LC50 of NExBTL renewable diesel vapour
(comprising predominately i-C16 to i-C18) will exceed 20 mg/l, although
exposure to such concentrations is unlikely given the low saturated
vapour concentration of the components present.
No classification for acute oral or acute
dermal toxicity required under Directive 67/548/EEC or Regulation EC
1272/2008 (oral and dermal LD50 both exceed 2000 mg/kg bwt). No
classification for acute inhalation (vapour) toxicity based on
read-across to related C9 -C13 n-alkanes.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again