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Registration Dossier
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EC number: 618-882-6 | CAS number: 928771-01-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Modern non-GLP, non-guideline experimental investigation
Data source
Reference
- Reference Type:
- publication
- Title:
- Inhalation kinetics of C8 to C10 1-alkenes and iso-alkanes in the rat after repeated exposures
- Author:
- Zahlsen, K, Eide, I, Nilsen, AM and Nilsen, OG
- Year:
- 1 993
- Bibliographic source:
- Pharmacology and Toxicology 73, 163-168
Materials and methods
- Objective of study:
- toxicokinetics
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The toxicokinetics of C8, C9 and C10 iso-alkanes in blood and selected body tissues was investigated in groups of male rats exposed to 100 ppm vapour (12 hr/d for 3 d)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-methyl heptane
- IUPAC Name:
- 2-methyl heptane
- Reference substance name:
- 2-methyl octane
- IUPAC Name:
- 2-methyl octane
- Reference substance name:
- 2-methyl nonane
- IUPAC Name:
- 2-methyl nonane
- Details on test material:
- 2-methyl heptane, CAS No. 592-27-8, C8H18 (>97%)
2-methyl octane, CAS No. 3221-61-2, C9H20 (>99%)
2-methyl nonane, CAS No. 871-83-0, C10H22 (>99%)
All supplied by Fluka AG, Buchs, Switzerland
Constituent 1
Constituent 2
Constituent 3
- Radiolabelling:
- no
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Mollegaard A/S, Skensved, Denmark
- Weight at study initiation: 150-200 g
- Housing: 4/cage
- Individual metabolism cages: no (4/cage)
- Diet : ad libitum (no further details)
- Water : ad libitum (tap water)
- Acclimation period: 4-6 d
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- other: air
- Details on exposure:
- Animals were exposed whole body to a target concentration of 100 ppm test substance (5 m3/hr) while housed in conical 0.7 m3 steel chambers with glass door and walls. A total of 16 animals (housed in 4 cages) were exposed on each occasion. Temperature and relative humidity were maintained at 22-24 degrees C and 50-90%, respectively, during exposure.
- Duration and frequency of treatment / exposure:
- 12 hr/d for 3 d
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 ppm vapour
- No. of animals per sex per dose / concentration:
- 4 males per substance per time point
- Control animals:
- no
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Tissue concentrations increased with increasing number of carbon atoms (C10 > C9 > C8)
- Details on distribution in tissues:
- Tissue concentrations were greatest in fat and lowest in blood (fat >> kidney, brain, liver >> blood).
- Details on excretion:
- Mean concentrations in fat immediately post-exposure was approx. 175-900 umol/kg decreasing to approx. 100-450 umol/kg 12 hr post-exposure. Mean concentrations in blood immediately following exposure were approx. 3-7 umol/kg and undetectable 12 hr post-exposure.
Any other information on results incl. tables
The
tissue concentration of various iso-alkanes tested increased with
increasing number of carbon atoms:
C10 > C9 > C8
The tissue concentration of iso-alkane was greatest in fat and lowest in
blood:
fat >> kidney, brain, liver >> blood
Mean concentrations in fat immediately following exposure were in an
approx. range 175-900 umol/kg, with approx. 100-450 umol/kg detectable
12 hr post-exposure.
Mean concentrations in kidney, liver and brain immediately following
exposure were in an approx. range 10-70 umol/kg and generally
undetectable at 12 hr post-exposure.
Mean concentrations in blood immediately following exposure were in an
approx. range 3-7 umol/kg, and undetectable at 12 hr post-exposure.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): other: Uptake and distribution of inhaled C8-C10 isoalkanes in body tissues, with rapid elimination from blood, brain, liver and kidney but slower from fat.
The concentration of iso-alkane in blood, brain, liver and fat increased with increasing number of carbon atoms. Detectable levels remained only in fat 12 hr post-exposure. - Executive summary:
The toxicokinetic properties of C8, C9 and C10 iso-alkanes were investigated in groups of male SD rats exposed by inhalation (100 ppm, 12 hr/d for 3 d), with the concentration of each in blood, brain, liver, kidney and perirenal fat determined using headspace GC immediately following each daily exposure and also 12 hr after the final exposure. The tissue concentration of the various iso-alkanes increased with increasing number of carbon atoms (C10 > C9 > C8), with analysed tissue concentrations being greatest in fat and lowest in blood (fat >> kidney, brain, liver >> blood). Detectable levels remained only in fat 12 hr post-exposure. The results indicate uptake and distribution of inhaled C8-C10 isoalkanes in body tissues, with rapid elimination from blood, brain, liver and kidney but slower removal from fat.
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