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EC number: 270-115-0
CAS number: 68411-30-3
An assumption that the test article aerosolized (a mix of water and the
test substance and other components) was a homologous mixture and that
this mixture was stable for the entire dosing period. Typically one
would conduct analytical measurements of the active material from the
sampled air from the test chamber (and not rely on a calculated value).
Instead the study assumes that the particles samples from the test
chamber contained the active ingredient based on the mathematical
calculation from dilution in water. If for some reason the particles
were not a homologous mix, then one could be over or under estimating
the air concentration of active material.
ALC is defined as the lowest atmospheric concentration generated that
caused death in 1 or more rats either on the day of exposure or within
14 days post exposure. No
mortality occurred at concentrations up to 260 mg/m3. At
310 mg/m3, one rat died during exposure and 2 rats died one
day post exposure. The
test material is considered moderately toxic by inhalation. However,
it is important to note that this laboratory exposure is not
representative of the possible LAS exposure during actual use. In
this study, animals were given high exposures to respirable-sized
particles (MMAD at 310mg/m3=
2.5 microns). Spray
products containing LAS are designed to produce large particle sizes. These
large particles are needed for efficient delivery of the spray to the
surface being cleaned. This
results in particle sizes that are much larger than the respirable
particle sizes used in testing and therefore would not be able to reach
far into the lungs where effects could occur. Given
this lack of relevance to real-world exposure potential, the use of this
study for risk assessment purposes is limited.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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