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EC number: 270-115-0
CAS number: 68411-30-3
The amount of test substance that penetrated the skin was below the
detection limit of 0.1 micrograms/cm2 or less than 0.3% of the initial
Radiolabelled test substance (3 mM solution) was applied to the shaved
skin of female rats. The exposure lasted 15 min, after which is was
rinsed off. After a 24 hr observation period during feces, urine, and
expired air was collected, the animals were sacrificed and the excised
skin was examined by autoradiography. Results show that the test
substance, which is of low solubility, did not penetrate through the
skin to any significant degree. The amount of test substance penetrating
the skin was below the detection limit. The penetration through rat skin
was < 0.3%.
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