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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to birds

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Administrative data

Endpoint:
toxicity to birds
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
no data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only a summary is provided.

Data source

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
other: see principles
Principles of method if other than guideline:
Wild-trapped birds were preconditioned to captivity for 2 to 6
weeks and were usually dosed by gavage with solutions or suspensions
of the test chemical in propylene glycol, according to
methods described by DeCino et al. (1966), Schafer (1972), and
Schafer et al. (1967). Other oral dosing methods were occasionally
used (pellets, gelatin capsules) but are not noted in the tables
(Schafer, 1972). LD50 values were calculated by the method of
Thompson (1948), Thompson and Wei! (1952), and Weil (1952).
Repellency tests were conducted by the methods of Starr et al.
(1964) and Schafer and Brunton (1971), and R50's (analogous to
LDso's) were calculated either by the method of Litchfield and
Wilcoxin (1949) or Thompson and Weil (1952).
A repellency-toxicity index (hazard factor) was calculated by
assuming that at the Rso level, a sixty-five g male redwing would
consume 50% of his approximate individual maximum food capacity
of 1 g. By making this assumption, it was possible to
estimate the mg/kg of a chemical that could conceivably be ingested
by a redwing at a given Rso level. This value, when divided
by the acute oral LD50, provides an index for indicating how
likely it would be for acute oral poisoning to occur in the wild. An
index value> 1.00 indicates well-accepted toxic agents that have
definite potential for causing acute poisoning episodes, an index
value ~0.25 ~ 1.00 indicates these compounds with a possible
potential, and an index value <0.25 indicates those compounds
with little or no potential to cause acute avian poisoning
episodes, at least in redwings.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Trientine
EC Number:
203-950-6
EC Name:
Trientine
Cas Number:
112-24-3
Molecular formula:
C6H18N4
IUPAC Name:
N,N'-bis(2-aminoethyl)ethane-1,2-diamine

Results and discussion

Effect levels
Duration (if not single dose):
18 h
Dose descriptor:
LD50
Effect level:
>= 100 - <= 133 mg/kg bw
Conc. / dose based on:
not specified
Basis for effect:
mortality

Applicant's summary and conclusion

Executive summary:

The acute oral toxicity, repellency, and hazard potential of 998 chemicals to one or more of 68 species of wild and domestic birds was determined by standardized testing procedures. Redwinged blackbirds were the most sensitive of the bird species tested on a large number of chemicals, and an index based on redwing toxicity and repellency may provide an appropriate indication of the probability of acute avian poisoning episodes. Avian repellency and toxicity were not positively correlated (i.e. toxicity varied independently with repellency).

For triethylene tetraamine (CAS 112 -24 -3) the LD50 was estimated based on the food consumption measured over a period of 18 hours. The LD50 is estimated at 101 mg/kg.