Prop-2-yn-1-ol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1963

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study was performed prior to the implementation of GLP and OECD Guidelines, but is in compliance with the principles described in OECD Guideline 401.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1963

Report date:

1963

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

not applicable

Principles of method if other than guideline:

Study was performed before the implementation of OECD Guidelines, but followed in principle the test procedure described in OECD Guideline 401.

GLP compliance:

no

Remarks:

test predated GLP

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Prop-2-yn-1-ol

EC Number:

203-471-2

EC Name:

Prop-2-yn-1-ol

Cas Number:

107-19-7

Molecular formula:

C3H4O

IUPAC Name:

prop-2-yn-1-ol

Details on test material:

No data

Test animals

Species:

rat

Strain:

not specified

Sex:

male/female

Details on test animals or test system and environmental conditions:

Young adult laboratory rats were purchased from a breeder. Usually the source and strain of the animals were not documented

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 1%

Doses:

Not indicated

No. of animals per sex per dose:

5 to 10 rats per sex and dose

Control animals:

no

Details on study design:

Several groups of 5 to 10 rats per sex and dose were treated simultaneously by gavage with preparations of the test substance in a suitable vehicle. The concentrations of these preparations were usually adjusted to achieve comparable volumes (e.g. 10 ml) per kg body weight.
Group-wise documentation of clinical signs was performed over the 7 day study period.
Body weight was determined before the start of the study only, as it was needed for determination of dose.
The clinical signs and findings were reported in summary form.
[More details e.g. on substance preparation, or dose and time dependence of symptoms, can be inferred from the German hand written raw data.]

Statistics:

On the basis of the observed lethality, the LD50 value was determined using a graphical evaluation of the dose response curve on probability paper.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

56.4 mg/kg bw

Mortality:

Mortality is only given as LD50

Clinical signs:

other: Agitation, hyperventilation, prone position

Gross pathology:

Some rats with hepatomegalia,
contents of the bowel with blood admixture,
lungs with petechial haemorrhages

Other findings:

No data

Applicant's summary and conclusion

Executive summary:

In an acute oral toxicity study a single oral dose of Propargyalcohol as a 1% solution in water was given to female and male rats at different doses. The rats were observed for 7 days. Agitation, hyperventilation and prone position of animals were noticed after application. The oral LD50 was estimated as 56.4 mg/kg bw.