Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 204-661-8 | CAS number: 123-91-1
Health surveillance data
Administrative data
- Endpoint:
- health surveillance data
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Human study in which basic data were given.
Data source
Reference
- Reference Type:
- publication
- Title:
- Mortality follow-up of workers exposed to 1,4-dioxane.
- Author:
- Buffler PA, Wood SM, Suarez L and Kilian DJ.
- Year:
- 1 978
- Bibliographic source:
- J. Occup. Med. 20 (4), 255-259.
Materials and methods
- Study type:
- health record from industry
- Endpoint addressed:
- carcinogenicity
Test guideline
- Qualifier:
- no guideline required
Test material
- Reference substance name:
- 1,4-dioxane
- EC Number:
- 204-661-8
- EC Name:
- 1,4-dioxane
- Cas Number:
- 123-91-1
- Molecular formula:
- C4H8O2
- IUPAC Name:
- 1,4-dioxane
Constituent 1
Method
- Type of population:
- occupational
- Ethical approval:
- not specified
Results and discussion
- Results:
- A mortality study conducted on 165 employees engaged for one month to ten years or more in 1,4-dioxane production and exposed (not continuously) to 1,4-dioxane concentrations below 90 mg/m3 showed no significant difference in observed deaths from overall cancer compared to the expected numbers.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
