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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature

Data source

Reference
Reference Type:
secondary source
Title:
Acute inhalation studies of glycol aerosols in rats - diethylene glycol, triethylene glycol, and 1,3-propanediol.
Author:
Cascieri T, Rinehart WE, Hoffman GM
Year:
1991
Bibliographic source:
Toxicologist 11: 145, Abstract 507, cited in MAK documentation 1995

Materials and methods

Principles of method if other than guideline:
Determination of the LC50 value.
GLP compliance:
no
Test type:
standard acute method

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-oxydiethanol
EC Number:
203-872-2
EC Name:
2,2'-oxydiethanol
Cas Number:
111-46-6
Molecular formula:
C4H10O3
IUPAC Name:
2-(2-hydroxyethoxy)ethan-1-ol

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: aerosol
Mass median aerodynamic diameter (MMAD):
>= 2.6 - <= 3.1 µm
Remark on MMAD/GSD:
The mass median aerodynamic diameter (MMAD) of particles ranged from 2.6 to 3.1 µm and 96% were below 10 µm.
Duration of exposure:
4 h
Concentrations:
Maximum attainable concentrations of 4.4 to 4.6 mg/L were tested. The test concentration was the highest technically available aerosol concentration.
No. of animals per sex per dose:
no data
Control animals:
not specified
Details on study design:
Duration of observation period following administration: 14 days

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LC50
Effect level:
> 4.6 mg/L air
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: no animals died during the 14-day observation period
Mortality:
No mortalities occurred.
Clinical signs:
other: Clinical signs of toxicity consisted of decreased activity during exposure with rapid recovery on removal and nasal discharge or lacrimation suggestive of minor irritation, persisting for several days.
Body weight:
A transient body weight loss with recovery within 3 to 5 days was reported.
Gross pathology:
Post mortem examinations were unremarkable.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met