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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
see below
Principles of method if other than guideline:
Thirty male rats of Charles River CD strain, weighting 200 to 260 grams, were divided equally into 6 groups. Single, oral doses of the test material, suspended in corn oil, were administered to rats that were fasted overnight. Observations for mortality were recorded daily for 14 days.
GLP compliance:
not specified
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-[(2-hydroperoxybutan-2-yl)peroxy]butane-2-peroxol; butane-2,2-diperoxol
EC Number:
700-954-4
Cas Number:
1338-23-4
Molecular formula:
Mixture of C4H10O4 and C8H18O6
IUPAC Name:
2-[(2-hydroperoxybutan-2-yl)peroxy]butane-2-peroxol; butane-2,2-diperoxol

Test animals

Species:
rat
Strain:
other: Charles River CD
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Weight at study initiation: 200 to 260 g
- Fasting period before study: fasting overnight

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
corn oil
Doses:
508.1, 807.1, 1281, 2034, 3229, 5126 mg/kg bw
No. of animals per sex per dose:
5 male rats per dose
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no
- Other examinations performed: body weight

Results and discussion

Effect levels
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
1 017 mg/kg bw
Based on:
test mat.
95% CL:
>= 879 - <= 1 175
Mortality:
No mortality was shown up to doses level 807.1 mg/kg bw. All other animals were dead up to days 1. Details see in the field "Any other information on results incl. tables".

Any other information on results incl. tables

Dose levels (mg/kg bw)

Number of dead animals

Total moralities

hours

days

508.1

0/4

 

 

 

807.1

0/5

 

 

 

1281

0/5

 

 

 

2034

5/5

 

 

 

3229

5/5

 

 

 

5126

5/5

 

 

 

Applicant's summary and conclusion

Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
The acute oral toxicity (LD50) value for methyl-ethylketone peroxide in DMP in male albino rats was calculated to be 1017 (879 - 1175) mg/kg.
Executive summary:

Methyl-ethylketone peroxide in DMP was tested in an acute oral toxicity study to thirty male rats of Charles River CD strain.

The thirty animals were divided equally into 6 groups. Single, oral doses of the test material, suspended in corn oil, were administered to rats that were fasted overnight. Observations for mortality were recorded daily for 14 days.

The acute oral toxicity (LD50) value for methyl-ethylketone peroxide in male albino rats was calculated to be 1017 (879 - 1175) mg/kg .