Registration Dossier
Registration Dossier
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EC number: 236-675-5 | CAS number: 13463-67-7
Other distribution data
Administrative data
- Endpoint:
- other distribution data
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: See 'Remarks'
- Remarks:
- The reference contained in this short entry represents investigations on the transport behaviour of titanium dioxide nanoparticles in the environment, with very limited value for risk assessment purposes. The reference do not fulfil the criteria for quality, reliability and adequacy of experimental data for the fulfilment of data requirements under REACH and hazard assessment purposes (ECHA guidance R4 in conjunction with regulation (EC) 1907/2006, Annexes VII-X). The information contained therein were included for information purposes only.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The transport of radioactive-labeled titanium dioxide nanoparticles ([48V]TiO2 NP) through columns filled with either sand (125-200 µm) or sediment (63-250 µm) was investigated by radioactivity measurement in the eluate. A solution of fulvic acid in distilled water (5 mg/L) with a flow rate of 1 ml/min was used as eluant.
- GLP compliance:
- not specified
- Remarks:
- not specified in study report
- Type of study:
- other: column transport
- Media:
- other: sand or sediment
Test material
- Reference substance name:
- Titanium dioxide
- EC Number:
- 236-675-5
- EC Name:
- Titanium dioxide
- Cas Number:
- 13463-67-7
- Molecular formula:
- O2Ti
- IUPAC Name:
- dioxotitanium
- Test material form:
- solid: nanoform
- Details on test material:
- - Name of test material (as cited in study report): radioactive-labeled titanium dioxide (Aeroxide P25, Evonik Industries (Degussa); anatase/rutile 80/20); TiO2 nanoparticles were activated by proton radiation to generate vanadium nuclides [48V], which decay to [48Ti] under emission of radioactive radiation.
- Particle size: 28 nm
- Purity: 96 %
Constituent 1
Results and discussion
Any other information on results incl. tables
A retention of 8 % and 18 % in sand and sediment, respectively, of [48V]TiO2 nanoparticles was observed. However,the study has several methodological shortcomings so that reported effects cannot be considered reliable for the risk assessment: Tests were conducted without addition of ions, although ionic strength significantly influences transport of TiO2 NP; all tests were conducted in the presence of fulvic acid; TiO2 suspension was pumped through the column instead of being applied to the surface of the test column and irrigated with artificial rain as specified in OECD 312 ("Leaching in soil columns"); the number of replicates is not reported.
Applicant's summary and conclusion
- Conclusions:
- The study has methodological shortcomings so that reported effects cannot be considered reliable.
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