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EC number: 931-597-4
CAS number: -
A preliminary trial and dose
range-finding study carried out prior to the 28-day oral toxicity study
in rats provides adequate information on acute oral toxicity of Ash in
rats. In this study groups of 3 male and 3 female rats (altogether 24
rats) were assigned into 4 treatment groups and received Ash in 1%
carboxymethyl cellulose by oral gavage at dose-levels of 0, 250, 500 or
1000 mg/kg bw /day for 7 consecutive days. The rats were observed for
mortality and clinical signs, food consumption and body weight
development. A functional and neurobehavioural test was carried out
before dosing and on days 1 and 7. On day 8 the animals were necropsied
and examined macroscopically. There was no mortality and no clinical
sign in males and females dosed with the vehicle or with Ash at any dose
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