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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: unsuitable test system for a solid test substance

Data source

Referenceopen allclose all

Reference Type:
study report
Title:
Unnamed
Year:
1978
Report Date:
1978
Reference Type:
secondary source
Title:
C.I. Pigment Brown 24
Author:
OECD
Year:
2002
Bibliographic source:
SIDS Initial Assessment Report for SIAM 15

Materials and methods

Principles of method if other than guideline:
The inhalation hazard test (IHT; synonymous to IRT, inhalation hazard test) was performed in principle as described in OECD Guideline 403 and in accordance to Smyth et al., Am.Ind.Hyg.Ass.J. 23,95-107 (1962). The aim of the test was to demonstrate the toxicity of an atmosphere saturated with vapors of the volatile components of the test substance at a temperature chosen for vapor generation (i.e. 20 °C for the present test substance).
The animals were exposed to the test substance for 7 hours (flow-through, 200 liters/hour).
GLP compliance:
no
Test type:
other: IHT

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female
Details on test animals and environmental conditions:
TEST ANIMALS
- Weight at study initiation: males 190 g/ females 170 g

Administration / exposure

Route of administration:
inhalation: vapour
Analytical verification of test atmosphere concentrations:
no
Remarks:
The nominal concentration was recalculated regarding the air flow and the test substance loss
Duration of exposure:
7 h
Concentrations:
0.1 mg/l
No. of animals per sex per dose:
6
Control animals:
no

Results and discussion

Effect levels
Key result
Dose descriptor:
other: IHT
Remarks on result:
other: No mortality within 7 hours in a saturated atmosphere.
Mortality:
none
Clinical signs:
nothing abnormal observed
Gross pathology:
nothing abnormal observed

Applicant's summary and conclusion