Chrome antimony titanium buff rutile

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

study report

Title:

Unnamed

Year:

1978

Report date:

1978

Reference 2

Reference Type:

secondary source

Title:

C.I. Pigment Brown 24

Author:

OECD

Year:

2002

Bibliographic source:

SIDS Initial Assessment Report for SIAM 15

Materials and methods

Principles of method if other than guideline:

BASF test: The study was conducted according to an internal BASF method which in principle is comparable to the OECD Guideline 401. A test group consisting of 10 animals/sex was treated by single gavage with an aqueous suspension of the test substance. The animals were observed for mortality and for clinical symptoms of toxicity. They were weighed prior to treatment only. At the end of the observation period of 14 days, the surviving animals were sacrificed for the purpose of necropsy.

GLP compliance:

no

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Chrome antimony titanium buff rutile

EC Number:

269-052-1

EC Name:

Chrome antimony titanium buff rutile

Cas Number:

68186-90-3

Molecular formula:

(Ti, Sb, Cr) O2

IUPAC Name:

manganese(4+) trititanium(4+) pentaantimony(3+) chromium(3+) nickel(2+) octadecaoxidandiide

Test material form:

solid

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Fasting period before study: 16 h
- Housing: Makrolon Typ III (maximum 5 animals per cage)
- Diet: standard pellet diet for mice and rats, ad libitum
- Water: ad libitum
- Acclimation period: 3-7 d

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22+/-1
- Humidity (%): 55+/-10
- Photoperiod (hrs dark / hrs light): 12/12

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

CMC (carboxymethyl cellulose)

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 0.5%

MAXIMUM DOSE VOLUME APPLIED: 31.6 mL/kg

Doses:

10000 mg/kg bw

No. of animals per sex per dose:

10

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observations were performed within the first 15 min after application and 30 min, 1 h, 2 h, 4 h, 5 h, 24 h after application; subsequently at least once daily. Animals were weighed directly before the application.
- Necropsy of survivors performed: yes

Statistics:

not performed

Results and discussion

Effect levels

Effect levels 1

Key result

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 10 000 mg/kg bw

Based on:

test mat.

Effect levels 2

Sex:

male/female

Dose descriptor:

LD0

Effect level:

>= 10 000 mg/kg bw

Based on:

test mat.

Mortality:

none

Clinical signs:

other: Nothing abnormal observed.

Gross pathology:

Nothing abnormal observed.

Applicant's summary and conclusion

Interpretation of results:

GHS criteria not met