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EC number: 269-052-1
CAS number: 68186-90-3
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77310.
Acute toxicity via oral route:
oral LD50 rat > 10000 mg/kg bw
(standardized test protocol; BASF 1978)
Acute toxicity via inhalation route:
Acute toxicity via dermal route:
No mortality or
systemic toxicity was observed in a 7-h
inhalation hazard test (IHT, BASF, 1978) and
in a 5-d bioavailability study (BASF,
33I0110/91008, 1994; see section 7.5.2).
Acute toxicity via oral route:
For the oral exposure pathway a limit test
is available, performed according to a standardized internal method,
which is in principle comparable to the OECD guideline 401, but for
which GLP compliance was not confirmed (BASF 1978). Since there were
no mortalities, clinical signs or necropsy findings observed in male
and female rats dosed with 10000 mg/kg bw after the 14 d observation
period, the acute oral LD50 is > 10000 mg/kg bw and the LD0 is ≥ 10000
mg/kg bw in rats.
The result of the key study is
supported by two supporting studies, which reveled an LD50 >5000
mg/kg and >10000 mg/kg (Ishihara Sangyo Kaisha 1985; Bayer 1972).
Acute toxicity via
No data were available for
acute dermal toxicity. In accordance with Regulation (EC)
1907/2006 (REACH), the acute dermal route was waived as the
substance does not meet the criteria for classification as
acute toxicity or STOT SE by the oral route (LD50 >2000
mg/kg, see section 7.2.1). Additionally, no systemic effects
have been observed in the in vivo studies with dermal
exposure (see section 7.3.1).
Acute toxicity via inhaltion route:
For the acute inhalation via the
inhalation route two studies were considered in a weight of
evidence approach. An acute inhalation hazard test (IHT),
performed in principle as described in the OECD Guideline 403, is
available (BASF, 1978). In this study, rats were exposed for a
period of 7 hours to an atmosphere saturated with vapors of the
volatile components of the test substance at 20 °C. No mortality
was observed during this test.
Additionally, a valid subacute
inhalation study was performed in rats only with an analogous
substance, the nickel rutile. In a GLP compliant bioavailability
study, male Wistar rats were exposed for 5 d to 60 mg/m³ of the
test substance; the observation period was 0, 3, 10, 31 and 60 d
(BASF, 33I0110/91008, 1994). No effects on mortality, clinical
signs, body weights and body weight gains were found. Clearance
half time was approximately 50 d in the lung. The study was not
able to demonstrate bioavailability after inhalation of the test
Classification, Labelling, and
Packaging Regulation (EC) No 1272/2008
The available experimental test data
are reliable and suitable for classification purposes under Regulation
1272/2008. Based on the available toxicity data and the
physical-chemical properties of the test substance, it is not classified
according to Regulation (EC) No 1272/2008 (CLP), as amended for the
ninth time in Regulation (EC) No 2016/1179.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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