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EC number: 269-052-1
CAS number: 68186-90-3
This substance is identified in the Colour Index by Colour Index Constitution Number, C.I. 77310.
As defined in Part B, Section 1 of the Chemical Safety Report, the
substance is an inorganic compound with very low solubility. Therefore,
there are no mandatory testing requirements for any of the required
ecotoxicological endpoints. As a result, the determination of PNEC
levels for this substance that are based on ecotoxicological studies
cannot be conducted.
A transformation/dissolution test according to OECD 29 with the
substance, however, demonstrated that small amounts of the individual
inorganic building blocks of this substance (i.e., the elements Chromium
and Antimony) could be released in aqueous media. It was shown in a
screening test that the highest release of Cr and Sb occurred at pH 8.5.
Therefore, it was decided to conduct the full test at the most relevant
pH with respect to ecotoxicology, i.e. at pH 8.5. Furthermore, Sb is of
no eco-toxicological relevance compared to Cr given by the available
aquatic endpoints derived from test with aquatic organisms: The acute
and chronic ERV for Antimony is 1770 and > 1000 µg Sb/L (European Union
Risk Assessment Report, 2008, see: https://echa.europa.eu/documents/10162/13630/trd_rar_sweden_diantimony_trioxide_en.rtf).
For CrIII the acute ERV is 320 µg/L and the chronic ERV is 47 µg /L for
acidic and alkaline pH values. The acute and chronic (ERVs) which are
comparable to the most sensitive aquatic ecotoxicological endpoint were
taken from the report "Proposed Environmental Quality Standards for
Water Framework Directive" see https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/291229/scho0407blvq-e-e.pdf.
The third inorganic builing block titanium was not taken into
acoount here since it is not of any ecotoxicological relevance.
The transformation and dissolution of CrIII and Sb from the
substance was evaluated according to the T/D Protocol (OECD 29)
(transformation/dissolution protocol, see section 4.8 attached).
The full test was performed at 1, 10 and 100 mg/L loadings for 7
days and at 1 mg/L loading for 28 days and at the pH of maximum release
of the most metals, i.e. at pH 8.5.
The acute and chronic Ecotoxicity Reference Values (ERVs) for Cr
were taken from a document prepared by EA UK, 2008: Proposed
Environmental Quality Standards for Water Framework Directive:
The acute ERV is 320 µg Cr/L and the chronic ERV is 47 µg Cr/L for
acidic and alkaline pH values. The mean Cr concentration of three
replicates/concentrations was 0.07, 0.13 and 0.28 µg Cr/L at a loading
rate of 1, 10 and 100 mg/L and after 7 days.
The acute and chronic ERV of Antimony is 1770 and > 1000 µg Sb/L
and were taken from the European Union Risk Assessment Report. The mean
Sb concentration of three replicates/concentrations was 0.77, 2.26 and
7.7 µg Sb/L at a loading rate of 1, 10 and 100 mg/L and after 7 days.
Consequently, the concentrations of Cr and Sb are far below the
acute ERVs of 320 µg/L for Cr and 1770 µg/L for Sb and thus, the
compound has not to be acutely classified according to GHS. This is in
line with the available aquatic ecotoxicological studies: In short-term
toxicity studies, performed with the test substance, no effect were
observed up to the limit dose and the following L(E)C50 values were
determined (nominal concentrations): LC50 (fish) > 10000.0 mg/L, EC50
(daphnia) > 100.0 mg/L and EC50 (algae) > 100.0 mg/L.
Based on these results, the test substance is not considered to be
classified for acute aquatic toxicity.
According to theT/D Protocol (OECD 29), the solubility equilibrium
has been established for Cr at the loadings of 1 mg/L, 10 mg/L and 100
mg/L because the concentrations of the last three sampling points do not
differ by more than 15%. These requirements are also fulfilled for
Antimony for 1 mg/L loading. After 28 days, the mean measured
concentrations were 0.06 and 1.0 µg/L for Cr and Sb, respectively. These
concentrations are far below the chronic ERVs (47 µg Cr/L and > 1000 µg
Sb/L) and thus no chronic classification has to be applied to the
substance according to GHS.
conclusion, the results according to the T/D Protocol compared with the
ERVs for the most ecotoxicological relevant metals of the substance
shows that the substance has not to be classified according to GHS
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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