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Diss Factsheets

Toxicological information

Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Follows basic scientific principles. Not a toxicological study, but provides supporting data to suggest the inorganic phosphates tested are tolerated in the diets of mammals.

Data source

Reference
Title:
Phosphorus Partitioning During Early Lactation in Dairy Cows Fed Diets Varying in Phosphorus Content
Author:
Knowlton KF and Herbein JH
Year:
2002
Bibliographic source:
J. Dairy Sci. 85:1227–1236

Materials and methods

Type of study / information:
Information on the use of phosphates as food additives for animals.
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The effect of dietary P content on P partitioning and excretion during early lactation was evaluated in 13 cows fed diets containing 0.34 (no supplementary P), 0.51, or 0.67% P. All cows were fed a common prepartum total mixed ration (TMR) (0.28% P), followed by common TMR (0.51% P) for 7 d post-partum. On day 7, cows were randomly assigned to one of the three dietary P treatments. All treatment diets contained 16.6% CP, 15.2% ADF, 26.3% NDF, and 0.74% Ca. Total collections of milk, urine, and feces were conducted during weeks 3, 5, 7, 9, and 11 of lactation.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Sodium dihydrogenorthophosphate
EC Number:
231-449-2
EC Name:
Sodium dihydrogenorthophosphate
Cas Number:
7558-80-7
Molecular formula:
H3O4P.Na
IUPAC Name:
sodium dihydrogen phosphate
Constituent 2
Chemical structure
Reference substance name:
Calcium hydrogenorthophosphate
EC Number:
231-826-1
EC Name:
Calcium hydrogenorthophosphate
Cas Number:
7757-93-9
Molecular formula:
CaHPO4
IUPAC Name:
calcium hydrogen phosphate
Details on test material:
- Name of test material (as cited in study report): monosodium phosphate and dicalcium phosphate

Results and discussion

Applicant's summary and conclusion

Conclusions:
Average body weight (591 kg), milk yield (47.9 kg/d), and DMI (25.2 kg/d) throughout the 10-wk trial were not affected by dietary P content. With increasing dietary P, however, linear increases in P intake (84.7, 135.2, and 161.5 g/d), fecal P (42.3, 87.5, and 108.6 g/d), urinary P (0.32, 1.28, and 3.90 g/d), and total P excretion (42.6, 88.8, and 112.5 g/d) were observed. Apparent P digestibility (49.0, 34.4, and 32.8% of P intake) decreased quadratically with increasing dietary P. Phosphorus balance was highly variable, but cows fed the 0.34% P diet were in negative P balance longer than were cows fed diets containing 0.51 or 0.67% P. With increasing dietary P, serum concentrations of inorganic P increased linearly, but serum Ca and Mg concentrations decreased. Increasing dietary P increased fecal and urinary P excretion in early lactation cows. Increased duration of negative P balance and changes in blood mineral concentrations suggest that cows fed low P diets mobilized more P from body reserves than cows on medium- and high-
P diets.