2-ethylhexyl acrylate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Basic data given: scientifically acceptable study report

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1958

Report date:

1958

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

BASF Test, observation period of 7 days

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl acrylate

EC Number:

203-080-7

EC Name:

2-ethylhexyl acrylate

Cas Number:

103-11-7

Molecular formula:

C11H20O2

IUPAC Name:

2-ethylhexyl acrylate

Details on test material:

- Test substance: 2-ethylhexyl acrylate
- Chemical name: 2-propenoic acid, 2-ethylhexyl ester
- Analytical Purity: no data
- Impurities: stabilised with 0.05 % hydrochinone
- Density: 0.887 g/cm3 (DIN 51757, cited in EU RAR, 2005)

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Mean body weight at test start: 142.0 g

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

other: aqueous emulsion with traganth (10 %)

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 10 %
- Amount of vehicle (if gavage): 4.51 mL/kg bw


MAXIMUM DOSE VOLUME APPLIED: 5.01 mL/kg bw

Doses:

2.040, 3.160, and 5.010 mL/kg bw (corresponding to 1809.5, 2802.9, and 4443.9 mg/kg bw)

No. of animals per sex per dose:

5 animals (1809.5, 2802.9 mg/kg bw), 10 animals (4443.9 mg/kg bw)

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Frequency of observations: after 1 h, 24 h, 48 h, and 7 d
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Statistics:

On the basis of the observed lethality, the LD50 value was estimated or determined using a graphical evaluation of the dose response curve on probability paper.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 4 435 mg/kg bw

Mortality:

LD50:
Original value: approx. 5.0 mL/kg bw; therefore LD50 = approx. 4435 mg/kg bw (density: 0.887 g/mL)

Clinical signs:

other: 1809.5 mg/kg bw: on the day of administration no findings; on the following day ruffled fur. 2802.9 mg/kg bw: 2 hours after administration staggering, slight abdominal position; on the following day no clinical signs apart from ruffled fur. 4443.9 mg/kg

Gross pathology:

Upon necropsy no macroscopic abnormalities were found.

Any other information on results incl. tables

Mortality:

Time	Dose level [mg/kg bw]
	1809.5	2802.9	4443.9
1 h	0/5	0/5	0/10
24 h	0/5	0/5	4/10
48 h	0/5	0/5	4/10
7 d	0/5	0/5	4/10

Applicant's summary and conclusion

Interpretation of results:

Category 5 based on GHS criteria

Executive summary:

Administration of 10% aqueous traganth solutions of 2-EHA (stabilised with 0.05% hydroquinone, no data on purity) to rats resulted in an oral LD50 value of 5.0 ml/kg (approximately 4,430 mg/kg). Clinical signs observed were apathy, narcotic state, and diarrhoea; no histologic alterations were detected, no further data are given.