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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
7 June - 16 July 1951
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1951
Report date:
1951

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Principles of method if other than guideline:
Test material was applied to the shaved skin of New Zealand albino rabbits for 24 hours. Survivors were examined for 14 days after dosing.
GLP compliance:
yes
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butan-1-ol
EC Number:
200-751-6
EC Name:
Butan-1-ol
Cas Number:
71-36-3
Molecular formula:
C4H10O
IUPAC Name:
butan-1-ol
Test material form:
liquid

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male
Details on test animals or test system and environmental conditions:
Male albino-New Zealand strain rabbits, 3 to 5 months of age and averaging 2.5 kg in weight were used.

Administration / exposure

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Details on dermal exposure:
Male albino New Zealand strain rabbits were immobilized during a 24-hour skin contact period. Thereafter, the "Vinylite" sheeting used to retain the dose in contact with the clipped skin of the trunk, was removed and the animals were caged for the remainder of the 14-day observation period.
Duration of exposure:
24-hour
Doses:
1.26, 2.52, 5.0 and 10.0 ml/kg
No. of animals per sex per dose:
4 male/dose
Control animals:
not specified
Details on study design:
Groups of 4 male rabbits were dosed with 1.26, 2.52, 5.0 or 10 ml/kg for a 24 hour period. Survivors were observed for a 14 day observation period following dosing.
Statistics:
Thompson method of calculating the LD50 was used.

Results and discussion

Effect levelsopen allclose all
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
ca. 3 430 mg/kg bw
Based on:
test mat.
Remarks on result:
other: converted value (calculated with a density of 0.81 g/mL)
Key result
Sex:
male
Dose descriptor:
LD50
Effect level:
4.24 mL/kg bw
Based on:
test mat.
95% CL:
3.02 - 5.95
Remarks on result:
other: original value
Mortality:
All rabbits survived following a dose of 1.26 or 2.52 ml/kg. One rabbit survived following a dose of 5.0 ml/kg. All rabbits died following a dose of 10 ml/kg. All deaths occurred on the day of dosing.
Clinical signs:
other: No additional information available.
Gross pathology:
No additional information available.
Other findings:
No additional information available.

Any other information on results incl. tables

No additional information available.

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria