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EC number: 215-125-8
CAS number: 1303-86-2
Boric acid was
tested in a Buehler method skin sensitisation test according to OECD 406
(Wnorowski, 1994) applied at a concentration of 95 % (powder moistened
with water) during both the induction and challenge phase of the test.
No signs of skin sensitisation were observed. No evidence of skin
sensitisation in humans exposed occupationally to borates has been
reported (Bruze et al., 1995).
Day of treatment
Very faint erythema (0.5) observed at one test site at 24 hours after first induction dose. No other irritation observed
No irritation observed
Very faint erythema (0.5) observed at two test sites at 24 hours after challenge dose. Irritation persisted at one site for 48 hours. Very faint erythema (0.5) observed at one test site at 24 hours in one naive control.
Results of skin sensitisation test:
Number of animals with signs of allergic reactions /number of animals in group
scored after 24h
0 / 10
0 / 20
scored after 48h
A skin sensitisation test on boric acid was
performed according to OECD Guideline 406 (Buehler method; Wnorowski,
1994). No sensitization studies with boric oxide were available. However,
boric oxide will exhibit properties identical to those of boric acid, as
it is an anhydride that will hydrolyse to give boric acid. Therefore the
data for boric acid can be read across to boric oxide for acute and
local toxicological effects. Please also refer to the read-across
statement attached to section 13.
There are no data to suggest that boric
oxide is a respiratory sensitiser.
Boric acid is not
a skin or respiratory sensitiser. In accordance with the criteria of EU
Regulation (EC) No 1272/2008) boric oxide does not need to be classified
and labelled as a skin or respiratory sensitizer.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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