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EC number: 239-701-3
CAS number: 15625-89-5
response data for each animal at each observation time up to removal of
each animal from the test
Score at time point / Reversibility
Erythema and Eschar formation
Max. score: 4
Average 24h, 48h, 72h
Reversibility (within 7 days)a
Average time (unit) for reversion
c. = completely reversible; n.c. = not completely reversible; n. = not
In a dermal irritation GLP study
performed according to the OECD guideline No. 404 (approved in July
1992), three young adult male White New-Zealand rabbits were dermally
exposed to 0.5 mL of test article for 4 hours to 6.25 cm² of clipped
skin in semi-occlusive conditions. Animals then were observed for 7
were scored again at 24, 48 and 72 hours and on day 7. The
skin was also evaluated for ulceration and necrosis or any evidence of
tissue destruction at these time periods.
Under the test conditions, there were
slightly irritant effects, with mean individual scores within 24, 48 and
72 hrs of 1.3/1.7/2.0 for erythema and 0.3/0.7/1.3 for edema.
These effects were not fully reversible within 7 days for one animal
only. Considering these scores the test substance is not
classified as irritating to the skin according to the criteria of Annex
VI to the Directive 67/548/EEC and CLP Regulation (EC) N° (1272-2008).
Index is 2.00
The author concludes: The test article is a dermal irritant but not
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