2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate; 2,2-bis(acryloyloxymethyl)butyl acrylate; trimethylolpropane triacrylate

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Study period:

1976

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study meets generally accepted scientific principles, acceptable for assessment

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1976

Report date:

1976

Materials and methods

Principles of method if other than guideline:

In an acute inhalation study, rats were exposed to the vapour of the test material at a single concentration for 6 h followed by observation for 14 d.

GLP compliance:

not specified

Test type:

fixed concentration procedure

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Trimethylolpropane Triacrylate (TMPTA)

IUPAC Name:

Trimethylolpropane Triacrylate (TMPTA)

Constituent 2

Reference substance name:

2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate

EC Number:

239-701-3

EC Name:

2-ethyl-2-[[(1-oxoallyl)oxy]methyl]-1,3-propanediyl diacrylate

Cas Number:

15625-89-5

Molecular formula:

C15H20O6

IUPAC Name:

2,2-bis(prop-2-enoyloxymethyl)butyl prop-2-enoate

Test animals

Species:

rat

Strain:

other: Charles River

Sex:

male/female

Details on test animals or test system and environmental conditions:

No data

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

other: unchanged (no vehicle)

Details on inhalation exposure:

GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Rate of air: 3.26 L/min.
- System of generating vapor: The vapor was generated by bubbling a stream of clean, dry air (-40 °C dewpoint) through the undiluted test material in a gas washing bottle.
- Temperature in air chamber: 24 °C
- Pressure in air chamber: 29.91 inches Hg

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

ca. 6 h

Concentrations:

0.55 mg/L air (nominal)

No. of animals per sex per dose:

5 animals per sex

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 d
- Necropsy of survivors performed: Yes
- Other examinations performed: Clinical signs and body weight

Statistics:

No data

Results and discussion

Preliminary study:

No data

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 0.55 mg/L air (nominal)

Exp. duration:

6 h

Mortality:

No mortality

Clinical signs:

other: No untoward reactions

Body weight:

Body weight gains were within the normal limits

Gross pathology:

No gross pathologic alterations

Other findings:

None

Applicant's summary and conclusion

Conclusions:

Under the test conditions, the inhalation LC50 of the test substance (trimethylolpropane triacrylate - TMPTA) was determined to be greater than 0.55 mg/L after 6 h exposure in rats.

Executive summary:

A study was conducted to evaluate the acute inhalation toxicity of the test substance (trimethylolpropane triacrylate - TMPTA) in rats.

5 Charles River rats/sex were exposed to the vapor of the test substance (trimethylolpropane triacrylate - TMPTA) at a single concentration of 0.55 mg/L air (nominal) for 6 h followed by and observation period of 14 days. Body weight was measured during the observation period and necropsy was performed at the end of this period.

There were no untoward reactions noted during exposure or during the 14 day observation period. The average body weight gains were within the normal limits. Necropsy, performed on all rats at the end of the observation period, did not reveal any gross pathologic alterations.

 

In conclusion, the single median lethal inhalation (LC50) of the test substance (trimethylolpropane triacrylate - TMPTA) was determined to be greater than 0.55 mg/L after 6 h exposure in rats.