Registration Dossier
Registration Dossier
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EC number: 204-127-4 | CAS number: 116-15-4
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
HFP may be systemically absorbed via the inhalation route. Based on its volatility and solubility, most of the absorbed HFP would likely be eliminated unchanged following inhalation. Metabolism of some of the systemically absorbed HFP is likely relevant to the observed nephrotoxicity associated with HFP. The results indicated that hexafluoropropene is metabolized to two different GSH-conjugates in rat liver and kidney. The data also strongly suggested that hexafluoropropene metabolites formed in the liver and eliminated with bile are not translocated to the kidney and that intrarenal bioactivation by GSH-conjugation may be responsible for hexafluoropropene-induced nephrotoxicity.
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