Registration Dossier
Registration Dossier
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EC number: 919-446-0 | CAS number: -
Endpoint summary
Administrative data
Description of key information
There is data available for this substance, which is presented in the dossier.
There was no experimental data available for this substance or structural analogues for long-term toxicity to fish and toxicity to microorganisms. For these endpoints, the aquatic toxicity was estimated using the PETROTOX computer model (v4.0), which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of nonpolar narcotic chemicals. PETROTOX computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
The substances are poorly soluble and made of constituents with various water solubility. As a consequence, the exposures were performed with Water Accommodated Fractions (WAFs). Therefore, the results are based on nominal loadings.
According to the harmonised CLP legislation (2008), Annex VI, this substance is classified for the environment as aquatic chronic category 2 with the hazard statement H411: Toxic to aquatic life with long lasting effects.
Additional information
Key and supporting information is summarised below:
Short-term toxicity to fish
Hydrocarbons C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) presented a 96-h LL50 (mortality) range forOncorhynchus mykiss of 10-30 mg/l (based on water accommodated fractions).
Long-term toxicity to fish
The long-term aquatic toxicity to fish was estimated using the PETROTOX computer model (v4.0), which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of nonpolar narcotic chemicals. PETROTOX computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
Short-term toxicity to aquatic invertebrates
Hydrocarbons C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) presented a 48-h EL50 (mobility) range forDaphnia magnaof 10 -22 mg/L (based on water accommodated fractions).
Long-term toxicity to aquatic invertebrates
Hydrocarbons C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) presented a 21 -d EL50 (reproduction) of 1.2 mg/l and 21 -d EC50 (reproduction) of 0.328 mg/l for Daphnia Magna. Reproduction was more sensitive than growth and survival, resulting in a NOELR of 0.28 mg/l and a NOEC of 0.097 mg/l.
Toxicity to algae and cyanobacteria
Hydrocarbons C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) presented a 72 -h EL50 (growth rate) of 4.1 mg/l and a 72-h NOELR (growth rate) of 0.76 mg/ for Pseudokirchneriella subcapitata(based on water accommodated fractions).
Hydrocarbons C9-C12, n-alkanes, isoalkanes, cyclics, aromatics (2-25%) presented 72-hour EbL50 (biomass) and ErL50 (growth rate) values within the range of 4.6-10 ml/L for Pseudokirchneriella subcapitata. The 72-hr NOEL values for biomass and growth rate were 0.22 and 1 mg/L, respectively. (Based on water accommodated fractions).
Toxicity to microorganisms
The toxicity to microorganisms was estimated using the PETROTOX computer model (v4.0), which combines a partitioning model used to calculate the aqueous concentration of hydrocarbon components as a function of substance loading with the Target Lipid Model used to calculate acute and chronic toxicity of nonpolar narcotic chemicals. PETROTOX computes toxicity based on the summation of the aqueous-phase concentrations of hydrocarbon block(s) that represent a hydrocarbon substance and membrane-water partitioning coefficients (KMW) that describe the partitioning of the hydrocarbons between the water and organism.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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