Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-411-2 | CAS number: 95-33-0
Endpoint summary
Administrative data
Description of key information
Additional information
A BCF of 924.7 l/kg is estimated on the basis of log Pow of 5 using the EPI Suite program, v.4.11. This is indicating that CBS is bioaccumulative.
In order to fulfill the information requirements especially for the PBT properties of CBS, the registrant proposes to perform a bioaccumulation test according to OECD guideline 305 dependent on the outcome of the assessment of the P criterion. For this reason, the Registrant has already proposed to first perform a simulation study in soil.
1. If the outcome of the preceding simulation test leads to the conclusion that CBS is P/vP, a bioaccumulation test shall be performed.
2. If the conclusion is not P/vP, a bioconcentration test shall not be performed.
Should establishing stable conditions for CBS not prove feasible owing to the hydrolytic behaviour of CBS, the test will be performed with a degradation product which is potentially found to be P/vP in the soil simulation test and if it fulfills the screening criterion for the B assessment.
According to EU-Risk Assessment from 2008, the described degradation products of CBS, MBT, BT, BTon, MBTS, MeSBT and MeBT are not bioaccumulative (BCF< 100). EU risk assessment 2008 reported a BCF of 3094 l/kg estimated by the equation log BCF = 0.85 log Pow - 0.70 (Veith et. al, 1979) with a log Pow of 4.93. This estimation is not taken into accout in current assessment, due to its limited training sets with only 55 diverse chemicals and its probabaly too broad application range of log Pow. The BCFBAF v3.02 from EPIWIN v4.11 was used instead as the most updated estimation program with more than 400 training sets. On the other hand, considering the fast hydrolysis property of CBS and the low bioaccumulativity of the metabolites, CBS should not be taken as PBT candidate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
