Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study was performed according to OECD guideline study with GLP compliance.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
6-phenyl-1,3,5-triazine-2,4-diyldiamine
EC Number:
202-095-6
EC Name:
6-phenyl-1,3,5-triazine-2,4-diyldiamine
Cas Number:
91-76-9
Molecular formula:
C9H9N5
IUPAC Name:
6-phenyl-1,3,5-triazine-2,4-diamine

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female

Administration / exposure

Vehicle:
CMC (carboxymethyl cellulose)
Doses:
0, 250, 500, 1000, 2000 mg/kg
No. of animals per sex per dose:
5
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
933 - 1 231 mg/kg bw
Remarks on result:
other: rat
Clinical signs:
other:

Any other information on results incl. tables

MORTALITY:number of deaths at each dose:

Concentration mg BG Number of animal Number of deaths
w/v%* /kg bw per sex male female
2.5 250 5 0 0
5.0 500 5 0 0
10.0 1000 5 3 1
20.0 2000 5 3 4
BG: benzoguanamine (6-phenyl-1 3 5-triazine-2 4-diyldiamine)
* at 10 ml/kg bw

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
LD50 value = 933 mg/kg (male)
Executive summary:

Test speices, strain: rat, Sprague-Dawley

The major toxicity: edema in the forestomach

Oral LD50Males: 933 mg/kg bw(95% C.L. = 838 to 1808 mg/kg bw)

Females: 1231mg/kg bw (95% C.I. = 583 to 1494 mg/kg bw)