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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Eye irritation

Currently viewing:

Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
other: laboratory worker exposure
Adequacy of study:
key study
Study period:
not specified
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The report presents the experience of workers engaged in animal laboratory studies using tetraethyl orthosilicate.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1940

Materials and methods

Principles of method if other than guideline:
Workers were exposed to vapours of tetraethyl orthosilicate during the handling and use of the material for laboratory studies in animals.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Tetraethyl orthosilicate
EC Number:
201-083-8
EC Name:
Tetraethyl orthosilicate
Cas Number:
78-10-4
Molecular formula:
C8H20O4Si
IUPAC Name:
tetraethyl orthosilicate

Test animals / tissue source

Species:
human

Test system

Vehicle:
unchanged (no vehicle)
Remarks:
worker exposure to vapours during laboratory studies in animals
Controls:
no
Amount / concentration applied:
85, 250, 700, 1200 and 3000 ppm, vapour
animal, and presumed worker, exposure concentrations
Duration of treatment / exposure:
"brief" exposure, details not specified
Observation period (in vivo):
none
Number of animals or in vitro replicates:
number workers exposed not specified
Details on study design:
Laboratory workers were exposed to tetraethyl orthosilicate vapours at the test concentrations used for guinea pig and rat vapour inhalation studies.

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
other: 3000 ppm, vapour
Basis:
other: worker
Time point:
other: not specified
Reversibility:
not specified
Remarks on result:
other: extremely irritating to eyes and nose of workers
Irritation parameter:
other: 1200 ppm, vapour
Basis:
other: worker
Time point:
other: not specified
Reversibility:
not specified
Remarks on result:
other: stings eyes and nose of and produces tears in workers
Irritation parameter:
other: 700 ppm, vapour
Basis:
other: worker
Time point:
other: not specified
Reversibility:
not specified
Remarks on result:
other: mildly stings eyes and nose of workers, 700 ppm could be tolerated by workers for approximately 30 minutes
Irritation parameter:
other: 250 ppm, vapour
Basis:
other: workers
Time point:
other: not specified
Reversibility:
not specified
Remarks on result:
other: makes eyes and nose of workers tingle slightly
Irritation parameter:
other: 85 ppm, vapour
Basis:
other: worker
Time point:
other: not specified
Reversibility:
not specified
Remarks on result:
other: can be detected as odor by workers

Applicant's summary and conclusion

Interpretation of results:
other: irritating to the human eye
Conclusions:
As the key eye data, workers exposed to tetraethyl orthosilicate vapours during pre-OECD guideline / pre-GLP laboratory animal studies showed irritation of the eyes and nose at concentrations of 250 ppm vapour (ca. 2.1 mg/L) and above. Concentrations of 700 ppm vapour (ca. 6.0 mg/L) could be tolerated by workers for approximately 30 minutes. This human finding is assigned reliability score 2. Compared to their studies in the guinea pig and rat (see 7.2.2.224), the authors concluded that human eyes and nose were more sensitive to tetraethyl orthosilicate vapours.

The eye irritant effects in laboratory workers support the Eye Irritation Cat 2 (H319, Causes serious eye irritation) classification in Annex VI of Regulation (EC) No. 1272/2008. This classification is assessed qualitatively as a "low hazard" for this endpoint following REACH Guidance Part E, Table E.3-1.