Registration Dossier
Registration Dossier
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EC number: 292-122-8 | CAS number: 90552-02-6
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Skin sensitisation
There are three actual guideline / GLP studies (OECD 429) available which represent the whole range of long-chain methacrylate esters from C12 to C22.
In these studies, the non-sensitising potential of the category was demonstrated.
Further studies on skin sensitisation available in the scientific literature, which show negative and positive test results are of insufficient reliability due to deficiencies as lack of test substance purity and characterisation, lack of control animals, deficiencies in test performance and in method description.
In conclusion, the long-chain alkyl methacrylate esters (C12 – C22) are determined as non-sensitising to skin.
Respiratory tract sensitisation
Due to the very low vapour pressure of the substances and the resulting lack of significant exposure, respiratory tract sensitisation is not considered as relevant.
Migrated from Short description of key information:
Skin sensitisation: In three actual guideline / GLP studies, the non-sensitising potential of the long-chain alkyl methacrylate esters (C12 - C22) was demonstrated. Further studies on skin sensitisation available in the scientific literature, which show negative and positive test results are of insufficient reliability due to deficiencies as lack of test substance purity and characterisation, lack of control animals, deficiencies in test performance and in method description.
In conclusion, the long-chain alkyl methacrylate esters (C12 – C22) are determined as non-sensitising to skin.
Respiratory tract sensitisation: Due to the very low vapour pressure of the substances and the resulting lack of significant exposure, respiratory tract sensitisation is not considered as relevant.
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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