2-Propenoic acid, 2-methyl-, C12-15-branched and linear alkyl esters

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Study period:

1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Limited documentation of the study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Guideline:

other: OSHA Toxicity Screening Test

GLP compliance:

no

Test type:

other: single dose

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Isodecyl methacrylate

EC Number:

249-978-2

EC Name:

Isodecyl methacrylate

Cas Number:

29964-84-9

IUPAC Name:

8-methylnonyl methacrylate

Test animals

Species:

rabbit

Strain:

New Zealand White

Administration / exposure

Doses:

Dosage: 3000 mg/kg

No. of animals per sex per dose:

6

Results and discussion

Effect levels

Dose descriptor:

LD50

Effect level:

> 3 000 mg/kg bw

Based on:

test mat.

Mortality:

In the observation period of 14 days, 2 of 6 experimental animals died.

Clinical signs:

other: As signs of intoxiciation, only hypoactivity was reported.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information

Conclusions:

In a dermal acute toxicity study on Isodecyl methacrylate with Albino Rabbits, an LD50 > 3000 mg/kg was observed.

Executive summary:

In an OSHA toxicity screening test in Albino rabbits on acute dermal toxicity with Isodecyl methacrylate, the test substance was administered undiluted with a dosage of 3000 mg/kg. b.w.

As sign of intoxication, hypoactivity is reported.

The determined LD50 was > 3000 mg/kg.

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