2-Propenoic acid, 2-methyl-, C12-15-branched and linear alkyl esters

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Study period:

25-10-1988 - 08-11-1988

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study OECD 401, GLP.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

Dodecyl methacrylate

EC Number:

205-570-6

EC Name:

Dodecyl methacrylate

Cas Number:

142-90-5

Molecular formula:

C16H30O2

IUPAC Name:

dodecyl methacrylate

Details on test material:

- Supplier: Evonik Röhm GmbH, D-64293 Darmstadt, Germany
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability of test article dilution: stable for at least 2 hr

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Doses:

5000 mg/kg b.w. and a gavage volume of 10 mL/kg b.w.

No. of animals per sex per dose:

5 males, 5 females per dose group

Control animals:

yes

Statistics:

The t-test was the adequate statistical value for comparison the results between the experimental and control groups.

Results and discussion

Preliminary study:

The limit dose of 5000 mg/kg b.w. were applied to the rats as a range finding dose.

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 5 000 mg/kg bw

Mortality:

Mortality was neigther observed in the experimental group nor in the controls during the observation period of 14 days.

Clinical signs:

other: The clinical appearance and behavior of the male and female rats did not differ from the controls for the whole experimental period, except of oily fouled skin in the rectum region of all experimental rats at the first day, and rough hair for the first tw

Gross pathology:

At necropsy substance-related signs of toxicity were not clearly obvious in comparison to the controls. The only observations were similar
incidences of red and white foci on the lung surface of the experimental and control rats. But in 2/5 male and 1/5 female rats slightly swollen liver
margins were observed for the experimental group only.
The results of the mean tissue weights show no differences between the experimental and control groups.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: OECD GHS