Registration Dossier
Registration Dossier
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EC number: 202-409-1 | CAS number: 95-31-8
Endpoint summary
Administrative data
Description of key information
Additional information
TBBS is not readily biodegradable with a biodegradability of 0% observed in 28 days (Bayer, 1991). The described main degradation products of TBBS are also not readily biodegradable.
According to the REACh Annex IX the degradation behaviour of TBBS should be further investigated in a simulation study in the most relevant compartment. The registrant intends to further elucidate the biodegradation in the compartment soil, as TBBS can be considered between moderately sorptive and highly or strongly (ad)sorptive based on its inherent properties logPow = 3.36 (exp. Duslo, 2007) and logKoc between 2.69 and 4.06 (calc. Currenta 2016).
TBBS is a member of the sulphenamide category and the category member N-cyclohexylbenzothiazole-2-sulphenamide (CBS, CAS 95-33-0, EC 202-411-2) exhibits an even higher adsorption potential (logKOW = 5.02, logKOC = 3.33 – 4.13) with a longer hydrolytic half-life t1/2 = 12.5 h. Based on these properties, a simulation study on ultimate degradation in soil (OECD 307) is planned on CBS to provide the necessary information on degradation potential of this highly adsorptive, hydrolytically unstable substance as detailed in ECHA Guidance R.7c (2017, p.29) to appropriately design a potential test on bioaccumulation.
If the OECD 307 on CBS results in not P, it will serve as proof of degradation of TBBS in soil following the above rationale (ECHA Guidance R.7b p. 233), as based on its physicochemical properties (higher adsorption, slower hydrolysis) CBS will serve as a worst case scenario.
If the OECD 307 on CBS will show that the more adsorptive substance must be classified as P, the registrant will consider further investigation on the degradation of TBBS in soil, to assess the remaining uncertainties from that result.
As a conclusion, a biodegradation simulation study in soil (OECD 307) is proposed by the registrant on CBS which appears to be more suitable to describe the degradation behaviour of CBS in the environment and might serve as a worst case scenario for the category member TBBS.
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