Registration Dossier
Registration Dossier
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EC number: 212-454-9 | CAS number: 818-61-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Groups of 5 male Sherman rats were administered doses of 126, 252, 500, 1000, and 2000 mg/kg bw by gavage. The animals were observed for lethality, changes in general appearance and demeanor and body weight gain during a 14-day post-exposure period.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-hydroxyethyl acrylate
- EC Number:
- 212-454-9
- EC Name:
- 2-hydroxyethyl acrylate
- Cas Number:
- 818-61-1
- Molecular formula:
- C5H8O3
- IUPAC Name:
- 2-hydroxyethyl acrylate
- Test material form:
- not specified
- Details on test material:
- not specified
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sherman
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: yes
ENVIRONMENTAL CONDITIONS
no details
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 10 % - Doses:
- 126, 252, 500, 1000, and 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, body weight - Statistics:
- Weil CS (1952). Biometrics 8: 249-263
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 540 mg/kg bw
- 95% CL:
- >= 390 - <= 750
- Mortality:
- At the highest dose of 2000 mg/kg bw 5/5 rats died within 2-24 hrs after dosing. At the doses of 1000 and 500 mg/kg bw 2/5 rats died within 24 hrs after administration. At the two lower doses of 252 and 126 mg/kg bw, no mortality occurred.
- Clinical signs:
- other: No changes in general appearance and demeanor were observed among any of the surviving animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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