Registration Dossier
Registration Dossier
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EC number: 212-454-9 | CAS number: 818-61-1
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Sensitization to patch test acrylates.
- Author:
- Kanerva L et al.
- Year:
- 1 988
- Bibliographic source:
- Contact Dermatitis 18: 10-15
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
- Principles of method if other than guideline:
- Data on allergic contact dermatitis from acrylates and 4 patients sensitized during routine patch testing were reported in the publication.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-hydroxyethyl acrylate
- EC Number:
- 212-454-9
- EC Name:
- 2-hydroxyethyl acrylate
- Cas Number:
- 818-61-1
- Molecular formula:
- C5H8O3
- IUPAC Name:
- 2-hydroxyethyl acrylate
- Test material form:
- not specified
- Details on test material:
- not specified
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2-Hydroxyethyl acrylate
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- no data
- Clinical history:
- no data
- Controls:
- no controls
- Route of administration:
- dermal
- Details on study design:
- Type of test used: patch test (epicutaneous test)
Administration:
- Type of application: occlusive (Finn chamber method)
- Description of patch: The tests are applied on the back with a non-occlusive porous tape (Scanpor© Surgical Tape, Norgeplaster A/S, Norway) or on the thighs and then closed by a Finn chamber.
- Vehicle / solvent: petrolatum
- Concentrations: 0.5 % (w/w)
- Testing/scoring schedule: The tests are read on removal and 24 h, 48 h, and 96-120 after removal (at least 3 readings).
- Removal of test substance: after 24 h
Examinations: All readings are made by a dermatologist.
Results and discussion
- Results of examinations:
- Observations during 1985-1986:
- Number of subjects with positive reactions: 3/24 (diagnosed as having an occupational allergic contact dermatitis to acrylates)
- Number of subjects with negative reactions 12/24
- Number of subjects with irritating reactions 9/24 (3 of these were actively sensitized to 2-HEA among other acrylates)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
