Registration Dossier
Registration Dossier
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EC number: 205-634-3 | CAS number: 144-62-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
- Species:
- mouse
- Strain:
- CBA
- Sex:
- female
- Vehicle:
- dimethyl sulphoxide
- Concentration:
- 12.5%, 25% and 50%
- No. of animals per dose:
- 3 test groups of 5 animal (3 different concentrations).
- Key result
- Parameter:
- SI
- Value:
- < 3
- Test group / Remarks:
- Concentration 12.5%
- Remarks on result:
- other: see Remark
- Remarks:
- None of the 3 concentrations tested reached the stimulation index of 3: The stimulation index at a concentration of 12.5% was of 2.6 The stimulation index at a concentration of 25% was of 1.9 The stimulation index at a concentration of 50% was of 2.5
- Key result
- Parameter:
- SI
- Value:
- < 3
- Test group / Remarks:
- Concentration 25%
- Remarks on result:
- other:
- Remarks:
- None of the 3 concentrations tested reached the stimulation index of 3: The stimulation index at a concentration of 12.5% was of 2.6 The stimulation index at a concentration of 25% was of 1.9 The stimulation index at a concentration of 50% was of 2.5
- Key result
- Parameter:
- SI
- Value:
- < 3
- Test group / Remarks:
- Concentration 50%
- Remarks on result:
- other:
- Remarks:
- None of the 3 concentrations tested reached the stimulation index of 3: The stimulation index at a concentration of 12.5% was of 2.6 The stimulation index at a concentration of 25% was of 1.9 The stimulation index at a concentration of 50% was of 2.5
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
- Conclusions:
- The EC3 value (derived by linear interpolation) could not be calculated as the
stimulation indices of all concentrations were below 3.
Consequently, according to OECD 429 and the criteria given in Annex I of Regulation (EC) 1272/2008, the test item Oxalic Acid, as described in this report is expected to have no sensitising properties and therefore, should not be regarded as a dermal sensitiser
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
