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Diss Factsheets

Physical & Chemical properties

Density

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
density, other
Remarks:
density
Type of information:
experimental study
Adequacy of study:
key study
Study period:
17/2/2016-17/2/2016
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Justification for type of information:
Experimental test result performed using standard test guidelines
Qualifier:
according to guideline
Guideline:
OECD Guideline 109 (Density of Liquids and Solids)
Principles of method if other than guideline:
The density of test item 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt (CAS No. 128-44-9) was determined following OECD guideline 109 and according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014.
GLP compliance:
no
Type of method:
pycnometer method
Specific details on test material used for the study:
- Name of test material: 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
- IUPAC name: 1,2-Benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt
- Molecular formula: C7H4NNaO3S
- Molecular weight: 205.169 g/mole
- Smiles: c12c(C(=O)[NH-]S1(=O)=O)cccc2.[Na+]
- InChI: 1S/C7H5NO3S.Na/c9-7-5-3-1-2-4-6(5)12(10,11)8-7;/h1-4H,(H,8,9);/q;+1/p-1
- Substance type: organic
- Physical state: Solid crystalline powder (white)
- Purity: 99.66%
Key result
Type:
pour density
Density:
0.871 g/cm³
Temp.:
27.4 °C
Remarks on result:
other: At 979 hPa.
Key result
Type:
tap density
Density:
0.909 g/cm³
Temp.:
27.4 °C
Remarks on result:
other: At 979 hPa.

Method Details

Observations

Remarks if, any

Guideline

OECD 109

1stReading

2ndReading

 

 

 

Method

Test methods: Pour density and tapped density of powders”recommended inThe International Pharmacopoeia, Fourth Edition, 2014[1]

 

 

Principle of method

Pour Density:It is the ratio of known weight of test item and its volume in graduated glass cylinder.

Tap Density:It is the difference between the volume of test item measured before & after tapping in the graduated glass cylinder.

 

 

Test temperature (°C)

-

27°C

27.8°C

Atmospheric pressure (in hPa)

-

978.9 hPa

979.1hPa

Weight of test item(m)

 

20 g

20 g

Volume of measuring cylinder; readability in g

 

250 ml;2 ml

250 ml ;2 ml

Volume of test item without tapping (V)

 

24 ml

22 ml

Volume of test item after tapping ( V1)

After 10 tapping

22 ml

22ml

 

After 50 tapping

22 ml

22ml

 

After 100 tapping

----

------

 

After 250 tapping

----

------

 

After 500 tapping

----

------

 

After 750 Tapping

----

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Conclusions:
The pour density and tapped of test item 1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt (CAS No. 128-44-9) was determined following OECD Guideline 109 and according to the according to the method recommended in the International Pharmacopoeia, fourth Edition, 2014 using bulk density apparatus . The pour density and tapped density of the test item was determine to be 0.8711 g/cm3 and 0.9090 g/cm3 at 27.4 Deg C and 979 hPa.
Executive summary:

The density of test item1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt(CAS No. 128-44-9) was determined following OECD guideline 109 and according to themethod recommended in the International Pharmacopoeia, fourth Edition, 2014. The pour density and tapped density of the test item was determine to be 0.8711 g/cm3 and 0.9090 g/cm3 at 27.4oC and  979 hPa.

Description of key information

The density of test item1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt(CAS No. 128-44-9) was determined following OECD guideline 109 and according to themethod recommended in the International Pharmacopoeia, fourth Edition, 2014. The pour density and tapped density of the test item was determine to be 0.8711 g/cm3 and 0.9090 g/cm3 at 27.4oC and  979 hPa.

Key value for chemical safety assessment

Additional information

The density of test item1,2-benzisothiazol-3(2H)-one 1,1-dioxide, sodium salt(CAS No. 128-44-9) was determined following OECD guideline 109 and according to themethod recommended in the International Pharmacopoeia, fourth Edition, 2014. The pour density and tapped density of the test item was determine to be 0.8711 g/cm3 and 0.9090 g/cm3 at 27.4oC and  979 hPa.

From other reliable sources & authoritative databases bulk density of 1,2 -benzisothiazol-3(2H)-one 1,1 -dioxide, sodium salt by the mass by volume method was determine to be 0.97 g/cm3 at room temperature of 25 °C .