Registration Dossier
Registration Dossier
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EC number: 201-286-1 | CAS number: 80-51-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Adequacy of study:
- supporting study
- Study period:
- 1950
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: The original reference is not available. This study was not conducted according to GLP standard.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- SIDS Initial Assessment Report for SIAM 22, 4,4'-Oxybis (benzenesulfonyl hydrazide) (OBSH)
- Author:
- OECD
- Year:
- 2 006
- Bibliographic source:
- OECD SIDS Assessment Report
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FIFRA Section 162.8 (c), March 1948
- Deviations:
- not specified
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 4,4'Oxybis(benzenesulfonyl hydrazide)
- IUPAC Name:
- 4,4'Oxybis(benzenesulfonyl hydrazide)
- Reference substance name:
- 4,4'-oxydi(benzenesulphonohydrazide)
- EC Number:
- 201-286-1
- EC Name:
- 4,4'-oxydi(benzenesulphonohydrazide)
- Cas Number:
- 80-51-3
- Molecular formula:
- C12H14N4O5S2
- IUPAC Name:
- 4-[4-(hydrazinesulfonyl)phenoxy]benzene-1-sulfonohydrazide
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- No data
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- The calculated dosage was first dissolved in distilled water and then placed onto gauze squares. The squares were immediately placed on the bare skin of each rabbit and securely held in place with waterproof adhesive tape. Care was taken to completely cover each patch securely so as to minimize evaporation and to insure continuous contact with the skin for 24 hours.
- Duration of exposure:
- 24 hours
- Doses:
- 200 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
- Details on study design:
- no data
- Statistics:
- no data
Results and discussion
- Preliminary study:
- NA
- Mortality:
- All animals were alive and well after the 24 hour period.
- Clinical signs:
- other: No toxic manifestations were exhibited by any of the animals under the test.
- Gross pathology:
- no data
- Other findings:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal acute toxicity of OBSH was evaluated in rabbit. The rabbits skin were in contact with a dose of 200mg/kg for 24 hours continuously.
The following observations were made after 24 hour exposure:
- All animals were alive and well after the 24 hour period
- No toxic manifestations were exhibited by any of the animals under the test. - Executive summary:
The dermal acute toxicity of OBSH was evaluated in rabbit. The rabbits skin were in contact with a dose of 200 mg/kg for 24 hours continuously.
The following observations were made after 24 hour exposure:
- All animals were alive and well after the 24 hour period
- No toxic manifestations were exhibited by any of the animals under the test.
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