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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1994
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 305 E (Bioaccumulation: Flow-through Fish Test)
Deviations:
not applicable
Principles of method if other than guideline:
NA
GLP compliance:
yes
Radiolabelling:
no
Test organisms (species):
Cyprinus sp.
Details on test organisms:
Cyprinus sp. (fish, fresh water)
Route of exposure:
aqueous
Water / sediment media type:
natural water: freshwater
Total exposure / uptake duration:
<= 42 d
Test temperature:
25 degrees celcius
Details on test conditions:
42 day(s) at 25 °C
A number of fish were exposed to 0.1 and 1 mg/l of the test substance solutions for 6 weeks
Reference substance (positive control):
not specified
Details on estimation of bioconcentration:
All measured values were lower than the detection limit, so a BCF could not be determined experimentally. Therefore, BCF values were calculated based on the limit of the detection of HPLC, 0.3 and 3 for 0.1 mg/l and 1mg/l of test concentrations, respectively.

BCF = 3.162
Type:
BCF
Value:
0.3 dimensionless
Remarks on result:
other: Conc.in environment / dose:0.1 mg/L
Type:
BCF
Value:
3 dimensionless
Remarks on result:
other: Conc.in environment / dose:1 mg/L
Details on kinetic parameters:
no data
Metabolites:
no data
Results with reference substance (positive control):
no data
Details on results:
All measured values were below the detection limit. Therefore, BCF values were calculated based on the limit of the detection of HPLC, 0.3 and 3 for 0.1 mg/l and 1mg/l of test concentrations, respectively
Validity criteria fulfilled:
not specified
Conclusions:
All measured values were lower than the detection limit. BCF values were, therefore, calculated based on the limit of the detection of HPLC, 0.3 and 3 for 0.1 mg/l and 1mg/l of test concentrations, respectively.
Executive summary:

A number of fish were exposed to 0.1 and 1 mg/l of the test substance solutions for 6 weeks.


All concentrations were below the detection limit. Therefore, BCF values were calculated based on the limit of the detection of HPLC; 0.3 and 3 for 0.1 mg/l and 1mg/l of test concentrations, respectively.


In conclusion, the test substance is not bioaccumulative in fish.

Description of key information

In a reliable study according to OECD 305, BCF values were calculated based on the limit of the detection of HPLC; for 0.1 mg/L test concentration a BCF of 0.3 and for 1 mg/L a BCF of 3 were calculated, respectively.


In a supporting study, a calculated BCD of 3.2 was derives by EpiSuite (BCFWIN v 2.15).

Key value for chemical safety assessment

BCF (aquatic species):
3 L/kg ww

Additional information

BCF was calculated by EpiSuite.