Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-041-9 | CAS number: 25723-16-4 1 - 6.5 moles propoxylated
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2008-05-15 to 2008-06-12
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: 2b Guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 A (Ready Biodegradability: DOC Die Away Test)
- Version / remarks:
- It is not clearly specified which version was used.
- Qualifier:
- according to guideline
- Guideline:
- other: SS-EN ISO 7827:1996
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Remarks:
- To maintain aerobic conditions in the mediums air was bubbled from an air pump through a long glass tube which ended at the bottom of the flask.
- Inoculum or test system:
- activated sludge, domestic (adaptation not specified)
- Details on inoculum:
- The inoculum was prepared from activated sludge taken from Klagshamm waste water plant, Sweden. The activated sludge contained 5.9 g suspended solids /l.
- Duration of test (contact time):
- 35 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 78
- Sampling time:
- 28 d
- Parameter:
- % degradation (DOC removal)
- Value:
- 80
- Sampling time:
- 28 d
- Details on results:
- The biodegradation test was prolongued to 35 days and after this time showed a plateau of approximately 89 % degradation.
The study report gives that the reference compound after 14 days was degraded more than 90 % without giving the reference substance identity. - Interpretation of results:
- readily biodegradable, but failing 10-day window
- Conclusions:
- Biodegradation was determined according to OECD method 301A and is given as 78 and 80 % after 28 days, however, failing the 10 -day window. Thus, the substance is regarded as not ready biodegradable.
- Executive summary:
Biodegradation was determined according to OECD method 301A and is given as 78 % and 80 % after 28 days, however, failing the 10 -day window. Thus, the substance is regarded as not ready biodegradable.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without detailed documentation.
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-D (Determination of the "Ready" Biodegradability - Manometric Respirometry Test)
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 100 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Test temperature: 20 +/- 1 °C - Parameter:
- % degradation (O2 consumption)
- Value:
- 6
- Sampling time:
- 4 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 49
- Sampling time:
- 12 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 61
- Sampling time:
- 14 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 80
- Sampling time:
- 20 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 84
- Sampling time:
- 28 d
- Details on results:
- Kinetic of test substance (in %):
6 after 4 day(s)
49 after 12 day(s)
61 after 14 day(s)
80 after 20 day(s)
84 after 26 day(s) - Results with reference substance:
- 90% after 28 days (Anilin)
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Mineralisation of 84% was observed for TMP propoxylated in a manometric test, hence the test material was considered as readily biodegradable.
Referenceopen allclose all
Description of key information
The % biodegradability for the substance was 84% in 26 days and therefore it can be considered as readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Biodegradation was determined according to OECD method 301A and in a manometric test. In the OECD301 A test, 78 % and 80 % biodegradation was observed after 28 days, however, failing the 10-day window. Thus, the substance is regarded as not ready biodegradable under the stringent conditions of the OECD 301 A. However, the manometric test is a more realistic simulation and in this test 84% biodegradation was observed. Therefore, the substance can be considered as readily biodegradable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
