Quinoline

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Study period:

August 1979

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Study performed according to a standard even if not EU, however the substance is poorly described, no observation is done at 48 h and after 72 h. The treatment duration is 24 h instead of 4.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1979

Report date:

1979

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: CFR Title 16, section 1500.41

Principles of method if other than guideline:

The exposure duration in this guideline is 24 h instead of 4 according to the OECD guideline.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Quinoline

EC Number:

202-051-6

EC Name:

Quinoline

Cas Number:

91-22-5

Molecular formula:

C9H7N

IUPAC Name:

quinoline

Details on test material:

- Name of test material (as cited in study report): 110 831
- Substance type: no data
- Physical state: no data
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data
- Isomers composition: no data
- Purity test date: no data
- Lot/batch No.: no data
- Expiration date of the lot/batch: no data
- Stability under test conditions: no data
- Storage condition of test material: no data

Test animals

Species:

rabbit

Strain:

not specified

Details on test animals or test system and environmental conditions:

no data

Test system

Type of coverage:

occlusive

Preparation of test site:

other: both intact and abraded

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

0.5 mL

Duration of treatment / exposure:

24 h

Observation period:

72 h

Number of animals:

6

Details on study design:

TEST SITE
- Area of exposure: 1 inch x 1 inch (around 2.5 cm x 2.5 cm)
- % coverage: no data
- Type of wrap if used: the patch is secured in place by adhesive tape. The entire trunk of the animal is then wrapped with an impervious material such as rubberized cloth.


REMOVAL OF TEST SUBSTANCE
- Washing (if done): no data
- Time after start of exposure: 24 h


SCORING SYSTEM: Draize score

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

erythema score

Remarks:

intact skin

Basis:

mean

Time point:

other: 24-72 h

Score:

0.9

Max. score:

3

Reversibility:

not reversible

Remarks:

over 72 h

Results 2

Irritation parameter:

edema score

Basis:

mean

Time point:

other: 24-72 h

Score:

1.5

Max. score:

3

Reversibility:

not reversible

Remarks:

over 72 h

Other effects:

1 animal died during the study

Any other information on results incl. tables

Animal	Effect	24 h		72 h
		Left side (intact)	Right side (abraded)	Left side (intact)	Right side (abraded)
1	Erythema	1	1	1	1
	Oedema	2	2	1	1
2	Erythema	0	0	0	0
	Oedema	2	2	0	0
3	Erythema	0	0	1	1
	Oedema	1	1	1	1
4	Erythema	1	1	2	2
	Oedema	3	3	1	1
5*	Erythema	-	-	-	-
	Oedema	-	-	-	-
6	Erythema	0	0	3	3
	Oedema	2	2	2	2

*Animal 5 died during the study

Applicant's summary and conclusion

Interpretation of results:

irritating

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

After exposure for 24 h, the mean scores are below 2 but the effects are not reversible over 72h, so the substance is considered as irritating R38 according to 67/548/EEC directive, and according to CLP (cat 2).

Executive summary:

The skin irritation properties of quinoline have been assessed in a test on 6 rabbits according to a US guideline (CFR Title 16, section 1500.41). The exposure duration was 24 h. The effects were observed at 24 and 72 h only. 1 rabbit died during the test.

The mean erythema score over 24 -72 h is 0.9 on intact skin and the mean oedema score is 1.5. However, the effects are not reversible at the end of the 72 h period, so the product is considered as irritating for the skin.