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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: No data on test method. No GLP.

Data source

Reference
Reference Type:
publication
Title:
Ueber das Schicksal cyklischer Terpene und Campher im thierischen Organismus. Dritte Mittheilung: Ueber das Verhalten des Camphers im Thierkörper.
Author:
Fromm E, Hildebrandt H, Clemens P
Year:
1903
Bibliographic source:
Zeitschrift für Physiologische Chemie 37: 189-202

Materials and methods

Objective of study:
metabolism
Principles of method if other than guideline:
The metabolism of Camphene was studied on rabbits. The test substance was administered by gavage, with olive oil as vehicle.
No more data provided on the method.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Camphene
EC Number:
201-234-8
EC Name:
Camphene
Cas Number:
79-92-5
Molecular formula:
C10H16
IUPAC Name:
2,2-dimethyl-3-methylidenebicyclo[2.2.1]heptane
Details on test material:
- Name of test material (as cited in study report): d-Camphen
Radiolabelling:
no

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
Duration and frequency of treatment / exposure:
No data
Doses / concentrations
Remarks:
Doses / Concentrations:
No data
No. of animals per sex per dose / concentration:
No data
Control animals:
not specified
Details on dosing and sampling:
METABOLITE CHARACTERISATION STUDIES
- Tissues and body fluids sampled (delete / add / specify): urine (as fresh as possible)

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
Camphene was the only studied terpene in rabbits that produced Glycuronic acid as a metabolite in the urine.

Any other information on results incl. tables

Camphene was the only studied terpene in rabbits that produced Glycuronic acid as a metabolite in the urine.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): other: (Camphene was the only studied terpene in rabbits that produced Glycuronic acid as a metabolite in the urine)
Camphene was the only studied terpene in rabbits that produced Glycuronic acid as a metabolite in the urine.
Executive summary:

The metabolism of Camphene was studied on rabbits. The test substance was administered by gavage, with olive oil as vehicle.

Camphene was the only studied terpene in rabbits that produced Glycuronic acid as a metabolite in the urine.