Registration Dossier
Registration Dossier
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EC number: 203-375-0 | CAS number: 106-22-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature available
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
- Reference Type:
- secondary source
- Title:
- Fragrance Raw Materials
- Author:
- Opdyke DLJ
- Year:
- 1 975
- Bibliographic source:
- Food Cosmet. Toxicol. 13, 757 - 758
- Reference Type:
- secondary source
- Title:
- RTECS: Update 199701, (2000/01)
- Author:
- Moreno OM
- Year:
- 2 001
- Bibliographic source:
- RTECS: Update 199701
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- acute dermal toxicity
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Citronellol
- EC Number:
- 203-375-0
- EC Name:
- Citronellol
- Cas Number:
- 106-22-9
- Molecular formula:
- C10H20O
- IUPAC Name:
- 3,7-dimethyloct-6-en-1-ol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- no data
- Doses:
- 1250, 2500, 5000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2 650 mg/kg bw
- 95% CL:
- 1 780 - 3 520
- Mortality:
- 5000 mg/kg bw: 5/5
2500 mg/kg bw: 2/5
1250 mg/kg bw: 0/5 - Clinical signs:
- other: 5000 mg/kg bw: ataxia and pupillary dilation 2500 mg/kg bw: ataxia in 4 animals 1250 mg/kg bw: 2 animals were weak and unable to stand
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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