(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate

Acute Toxicity: dermal

Administrative data

Endpoint:

acute toxicity: dermal

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study with GLP

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

review article or handbook

Title:

Unnamed

Year:

2000

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 402 (Acute Dermal Toxicity)

Deviations:

no

Principles of method if other than guideline:

There is no need to add in this field.

GLP compliance:

yes

Test type:

standard acute method

Limit test:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

425-220-8

EC Name:

-

Cas Number:

5945-33-5

Molecular formula:

C39H34O8P2

IUPAC Name:

(1-methylethylidene)di-4,1-phenylenetetraphenyl diphosphate

Details on test material:

75 - 95% (typical 88%, verified by UV/visible spectrum, Infrared (IR) spectrum, Nuclear Magnetic Resonance (NMR), and Mass spectrum.)

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

Nothing to add in this field.

Administration / exposure

Type of coverage:

semiocclusive

Vehicle:

water

Details on dermal exposure:

The test substance was moistened in water before application.
A dose of 2 000 mg/kg was applied under semiocclusive dressing to an area of shorn skin on the back and flank for 24 hours.

Duration of exposure:

24 hours

Doses:

2000 mg/kg

No. of animals per sex per dose:

5

Control animals:

not specified

Details on study design:

limit test

Statistics:

no data

Results and discussion

Preliminary study:

Nothing to add in this field.

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

> 2 000 mg/kg bw

Remarks on result:

other: Observation period: 14 days

Mortality:

no effect

Clinical signs:

no effect

Body weight:

All animals showed expected gain in bodyweight.

Gross pathology:

No signs of skin irritation were noted during the study. No abnormalities were noted at necropsy.

Other findings:

Nothing to add in this field.

Any other information on results incl. tables

Mortality: No deaths were recorded.

Clinical observations: No clinical signs of toxicity were noted.

Morphological findings: No signs of skin irritation were noted during the study. No abnormalities were noted at necropsy.

Comment: All animals showed expected gain in bodyweight.

LD50: > 2 000 mg/kg

Result: The test chemical was of low dermal toxicity in rats.

Applicant's summary and conclusion

Interpretation of results:

practically nontoxic

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

The test material has low toxicity via acute dermal toxicity study in rats.

Executive summary:

According to OECD TG 402, the acute dermal toxicity test was well conducted and the results indicated the test material has very low toxicity in rats.